Document Detail

Cerebellar blood flow in schizophrenic patients and normal control subjects.
MedLine Citation:
PMID:  7568566     Owner:  NLM     Status:  MEDLINE    
We used 133Xe dynamic single-photon emission computed tomography (DSPECT) to measure the resting cerebellar blood flow in 17 neuroleptic-free schizophrenic and schizophreniform patients and 13 normal control subjects. A subset of these subjects (11 patients and 7 control subjects) additionally underwent activation studies during the Wisconsin Card Sorting (WCS) and Number Matching (NM) tests. Baseline relative cerebellar blood flow was significantly lower in older patients than in age-matched control subjects. For absolute cerebellar flow, there was a significant difference between patients and control subjects in the overall activation response (patients: NM 13.4% increase, WCS 15.7% increase; control subjects: NM 3.1% decrease, WCS 0.0% change). This difference was more pronounced in older subjects. Cerebral blood flow significantly increased during NM (patients: 21.3% increase, control subjects: 6.5% increase) and WCS (patients: 16.5% increase, control subjects: 9.7% increase). The difference in the magnitude of cerebral NM activation between schizophrenic patients and control subjects, although not statistically significant, may call into question the appropriateness of using NM as a control task in schizophrenic patients. Finally, we found no differences between the effects of WCS and NM on cerebellar or cerebral blood flow. Because of the small number of subjects in each group, the results of this study should be interpreted cautiously.
J L Steinberg; M D Devous; F G Moeller; R G Paulman; J D Raese; R R Gregory
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Psychiatry research     Volume:  61     ISSN:  0165-1781     ISO Abbreviation:  Psychiatry Res     Publication Date:  1995 May 
Date Detail:
Created Date:  1995-11-09     Completed Date:  1995-11-09     Revised Date:  2008-04-17    
Medline Journal Info:
Nlm Unique ID:  7911385     Medline TA:  Psychiatry Res     Country:  IRELAND    
Other Details:
Languages:  eng     Pagination:  15-31     Citation Subset:  IM    
Psychiatry Service (116A), Department of Veterans Affairs Medical Center, Dallas, TX 75216, USA.
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MeSH Terms
Age Factors
Brain / blood supply,  physiopathology,  radionuclide imaging
Brain Diseases / diagnosis,  physiopathology,  radionuclide imaging
Cerebellum / blood supply*,  physiopathology*,  radionuclide imaging
Functional Laterality
Middle Aged
Neuropsychological Tests
Schizophrenia / diagnosis,  physiopathology*,  radionuclide imaging
Tomography, Emission-Computed, Single-Photon

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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