Document Detail

Cerebellar atrophy after acute phenytoin intoxication.
MedLine Citation:
PMID:  9118858     Owner:  NLM     Status:  MEDLINE    
There is some evidence that long-term phenytoin (PHT) use may occasionally give rise to irreversible cerebellar atrophy, but it is unclear whether such changes can occur after acute PHT intoxication. We describe a 38-year-old patient with accidental acute PHT overdose who developed severe cerebellar atrophy. This case provides evidence that acute PHT intoxication can, on rare occasions, result in irreversible cerebellar degeneration.
T Kuruvilla; N E Bharucha
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  38     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  1997 Apr 
Date Detail:
Created Date:  1997-04-23     Completed Date:  1997-04-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  500-2     Citation Subset:  IM    
Department of Neuroepidemiology, Bombay Hospital, India.
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MeSH Terms
Acute Disease
Cerebellar Diseases / chemically induced*,  pathology*
Cerebellum / pathology*
Magnetic Resonance Imaging
Phenytoin / poisoning*
Reg. No./Substance:

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