| Cerebellar hemorrhage on magnetic resonance imaging in preterm newborns associated with abnormal neurologic outcome. | |
| | |
MedLine Citation:
|
PMID: 20833401 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: To investigate the relationship between cerebellar hemorrhage in preterm infants seen on magnetic resonance imaging (MRI), but not on ultrasonography, and neurodevelopmental outcome. STUDY DESIGN: Images from a cohort study of MRI in preterm newborns were reviewed for cerebellar hemorrhage. The children were assessed at a mean age of 4.8 years with neurologic examination and developmental testing using the Wechsler Preschool and Primary Scale of Intelligence, Third Edition. RESULTS: Cerebellar hemorrhage was detected on both ultrasonography and MRI in 3 of the 131 preterm newborns evaluated, whereas smaller hemorrhages were seen only on MRI in 10 newborns (total incidence, 10%). Adjusting for gestational age at birth, intraventricular hemorrhage, and white matter injury, cerebellar hemorrhage detectable solely by MRI was associated with a 5-fold increased odds of abnormal neurologic examination compared with newborns without cerebellar hemorrhage (outcome data in 74%). No association with the Wechsler Preschool and Primary Scale of Intelligence, Third Edition score was found. CONCLUSIONS: Cerebellar hemorrhage is not uncommon in preterm newborns. Although associated with neurologic abnormalities, hemorrhage seen only on MRI is associated with much more optimistic outcomes than that visible on ultrasonography. |
| | |
Authors:
|
Emily W Y Tam; Glenn Rosenbluth; Elizabeth E Rogers; Donna M Ferriero; David Glidden; Ruth B Goldstein; Hannah C Glass; Robert E Piecuch; A James Barkovich |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't Date: 2010-09-15 |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 158 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-01-17 Completed Date: 2011-02-24 Revised Date: 2012-02-02 |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
|
Languages: eng Pagination: 245-50 Citation Subset: AIM; IM |
Copyright Information:
|
Copyright © 2011 Mosby, Inc. All rights reserved. |
Affiliation:
|
Department of Neurology, University of California San Francisco, San Francisco, CA, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Case-Control Studies Cerebellum / pathology* Cerebral Hemorrhage / complications, pathology*, ultrasonography Child, Preschool Cohort Studies Developmental Disabilities / epidemiology, etiology*, physiopathology Female Follow-Up Studies Humans Incidence Infant Infant, Newborn Infant, Premature* Intelligence Tests Linear Models Logistic Models Magnetic Resonance Imaging / methods* Male Neurologic Examination / methods Risk Assessment Severity of Illness Index Ultrasonography, Doppler |
| Grant Support | |
ID/Acronym/Agency:
|
K23 NS066137-02/NS/NINDS NIH HHS; KL2 RR024130-05/RR/NCRR NIH HHS; KL2RR024130/RR/NCRR NIH HHS; R01 NS046432-06/NS/NINDS NIH HHS; R01 NS046432-07/NS/NINDS NIH HHS; R01 NS346432/NS/NINDS NIH HHS; UL1 RR024131/RR/NCRR NIH HHS; UL1 RR024131-05/RR/NCRR NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Effects of an exercise program in children with cystic fibrosis: are there differences between femal...
Next Document: Inactivation of the gene katA or sodA affects the transient entry into the viable but non-culturable...