Document Detail

Cerebellar cleft: confirmation of the neuroimaging pattern.
MedLine Citation:
PMID:  20221959     Owner:  NLM     Status:  MEDLINE    
We recently described the neuroimaging and clinical findings in 6 children with cerebellar clefts and proposed that they result from disruptive changes following prenatal cerebellar hemorrhage. We now report an additional series of 9 patients analyzing the clinical and neuroimaging findings. The clefts were located in the left cerebellar hemisphere in 5 cases, in the right in 3, and bilaterally in one child who had bilateral cerebellar hemorrhages as a preterm infant at 30 weeks gestation. In one patient born at 24 weeks of gestation a unilateral cerebellar hemorrhage has been found at the age of 4 months. Other findings included disordered alignment of the folia and fissures, an irregular gray/white matter junction, and abnormal arborization of the white matter in all cases. Supratentorial abnormalities were found in 4 cases. All but 2 patients were born at term. We confirm the distinct neuroimaging pattern of cerebellar clefts. Considering the documented fetal cerebellar hemorrhage in our first series, we postulate that cerebellar clefts usually represent residual disruptive changes after a prenatal cerebellar hemorrhage. Exceptionally, as now documented in 2 patients, cerebellar clefts can be found after neonatal cerebellar hemorrhages in preterm infants. The short-term outcome in these children was variable.
A Poretti; T A G M Huisman; F M Cowan; E Del Giudice; P Y Jeannet; D Prayer; M A Rutherford; A J du Plessis; C Limperopoulos; E Boltshauser
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Publication Detail:
Type:  Journal Article     Date:  2010-03-10
Journal Detail:
Title:  Neuropediatrics     Volume:  40     ISSN:  1439-1899     ISO Abbreviation:  Neuropediatrics     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2010-03-11     Completed Date:  2010-06-15     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  8101187     Medline TA:  Neuropediatrics     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  228-33     Citation Subset:  IM    
Copyright Information:
(c) Georg Thieme Verlag KG Stuttgart . New York.
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MeSH Terms
Cerebellar Diseases / complications,  diagnosis*
Cerebellum / abnormalities*,  growth & development
Child, Preschool
Cognition Disorders / etiology
Dilatation, Pathologic / diagnosis*
Follow-Up Studies
Magnetic Resonance Imaging / methods*
Grant Support
MC_U120088465//Medical Research Council

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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