| Ceramides and barrier function in healthy skin. | |
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MedLine Citation:
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PMID: 20574598 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lipids in the stratum corneum are key components in the barrier function of the skin. Changes in lipid composition related to eczematous diseases are well known, but limited data are available on variations within healthy skin. The objective of the present study was to compare ceramide subgroups and ceramide/cholesterol ratios in young, old, male and female healthy skin. A total of 55 participants with healthy skin was included in the study. Lipid profiles were correlated with transepidermal water loss and with information on dry skin from a questionnaire including 16 people. No statistically significant differences were found between young and old skin for ceramide subgroups or ceramide/cholesterol ratios, and there was no statistically significant correlation between answers about dry skin and ceramide levels. Interestingly, a statistically significant higher ceramide/cholesterol ratio was found for men than for women (p = 0.02). |
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Authors:
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Jakob Mutanu Jungersted; Lars I Hellgren; Julie K Høgh; T Drachmann; Gregor B E Jemec; Tove Agner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Acta dermato-venereologica Volume: 90 ISSN: 1651-2057 ISO Abbreviation: Acta Derm. Venereol. Publication Date: 2010 Jul |
Date Detail:
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Created Date: 2010-06-24 Completed Date: 2010-10-12 Revised Date: 2012-01-02 |
Medline Journal Info:
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Nlm Unique ID: 0370310 Medline TA: Acta Derm Venereol Country: Sweden |
Other Details:
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Languages: eng Pagination: 350-3 Citation Subset: IM |
Affiliation:
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Department of Dermatology, University of Copenhagen, Roskilde Hospital, Roskilde, Denmark. Jungersted@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Ceramides / metabolism* Cholesterol / metabolism Denmark Female Humans Male Middle Aged Permeability Questionnaires Skin / metabolism* Skin Absorption* Water Loss, Insensible* Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Ceramides; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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