Document Detail


Ceramide participates in lysosome mediated cell death induced by type II anti-CD20 mAbs.
MedLine Citation:
PMID:  25393677     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
ABSTRACT Considering variable and often modest therapeutic efficacy of Rituximab for a substantial proportion of patients suffering from Non-Hodgkin lymphomas (NHLs), various type II anti-CD20 monoclonal antibodies (mAbs) with excellent ability in inducing programmed cell death (PCD) are developed for enhanced therapeutic index currently. Although homotypic adhesion (HA) and lysosome leakage are proved to be of vital importance in type II mAb induced PCD in NHL cells, the detailed relationship between them remains unclear. Herein, for the first time we discovered that the improved intracellular ceramide level is an important mediator between HA and lysosome leakage in Tositumomab induced cell death. Further experimental results revealed that the generation of intracellular ceramide acts as the outcome of HA and major cause of lysosome leakage. The clarification of ceramide involvement in type II anti-CD20 mAb induced PCD may provide new ideas in CD20 based immunotherapy against NHLs.
Authors:
Yuzhi Liu; Ling Shu; Jingjing Wu
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-13
Journal Detail:
Title:  Leukemia & lymphoma     Volume:  -     ISSN:  1029-2403     ISO Abbreviation:  Leuk. Lymphoma     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-11-13     Completed Date:  -     Revised Date:  2014-11-14    
Medline Journal Info:
Nlm Unique ID:  9007422     Medline TA:  Leuk Lymphoma     Country:  -    
Other Details:
Languages:  ENG     Pagination:  1-27     Citation Subset:  -    
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