Document Detail


Ceramide-1-phosphate regulates migration of multipotent stromal cells and endothelial progenitor cells--implications for tissue regeneration.
MedLine Citation:
PMID:  23193025     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ceramide-1-phosphate (C1P) is a bioactive lipid that, in contrast to ceramide, is an antiapoptotic molecule released from cells that are damaged and "leaky." As reported recently, C1P promotes migration of hematopoietic cells. In this article, we tested the hypothesis that C1P released upon tissue damage may play an underappreciated role in chemoattraction of various types of stem cells and endothelial cells involved in tissue/organ regeneration. We show for the first time that C1P is upregulated in damaged tissues and chemoattracts bone marrow (BM)-derived multipotent stromal cells, endothelial progenitor cells, and very small embryonic-like stem cells. Furthermore, compared to other bioactive lipids, C1P more potently chemoattracted human umbilical vein endothelial cells and stimulated tube formation by these cells. C1P also promoted in vivo vascularization of Matrigel implants and stimulated secretion of stromal cell-derived factor-1 from BM-derived fibroblasts. Thus, our data demonstrate, for the first time, that C1P is a potent bioactive lipid released from damaged cells that potentially plays an important and novel role in recruitment of stem/progenitor cells to damaged organs and may promote their vascularization.
Authors:
Chihwa Kim; Gabriela Schneider; Ahmed Abdel-Latif; Kasia Mierzejewska; Manjula Sunkara; Sylwia Borkowska; Janina Ratajczak; Andrew J Morris; Magda Kucia; Mariusz Z Ratajczak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Stem cells (Dayton, Ohio)     Volume:  31     ISSN:  1549-4918     ISO Abbreviation:  Stem Cells     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-26     Completed Date:  2014-01-07     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9304532     Medline TA:  Stem Cells     Country:  United States    
Other Details:
Languages:  eng     Pagination:  500-10     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 AlphaMed Press.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cell Growth Processes / physiology
Cell Movement / physiology*
Ceramides / biosynthesis,  metabolism*
Chemotactic Factors / biosynthesis,  metabolism
Human Umbilical Vein Endothelial Cells / cytology,  metabolism*
Humans
Mesenchymal Stromal Cells / cytology,  metabolism*
Mice
Mice, Inbred C57BL
Myocardial Ischemia / metabolism,  pathology
Regeneration / physiology*
Regenerative Medicine / methods
Stem Cells / cytology*,  metabolism
Up-Regulation
Grant Support
ID/Acronym/Agency:
R01 DK074720/DK/NIDDK NIH HHS; R01 HL112788/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Ceramides; 0/Chemotactic Factors; 0/ceramide 1-phosphate
Comments/Corrections

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