Document Detail


Cephradine (Velosef) penetration of mandibular bone.
MedLine Citation:
PMID:  2111359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The concentration of cephradine in serum and mandibular bone was assayed in 28 patients undergoing 3rd molar surgery following a single 1 g intravenous injection. Serum and cortical bone samples taken simultaneously, contained mean cephradine concentrations of 42.11 micrograms/ml and 2.61 micrograms/g respectively. These results, when compared with those reported for other bony sites including the femoral head and knee, show a reduced bone penetration with a bone-to-serum ratio of approximately 0.06:1.
Authors:
R J Middlehurst; J P Rood
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of oral and maxillofacial surgery     Volume:  19     ISSN:  0901-5027     ISO Abbreviation:  Int J Oral Maxillofac Surg     Publication Date:  1990 Apr 
Date Detail:
Created Date:  1990-06-25     Completed Date:  1990-06-25     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8605826     Medline TA:  Int J Oral Maxillofac Surg     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  120-1     Citation Subset:  D; IM    
Affiliation:
Department of Oral and Maxillofacial Surgery, Turner Dental School, University Dental Hospital of Manchester, England.
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MeSH Terms
Descriptor/Qualifier:
Adult
Cephalosporins / analysis*
Cephradine / administration & dosage,  analysis*,  blood
Female
Humans
Injections, Intravenous
Male
Mandible / analysis*
Molar, Third / surgery
Premedication
Time Factors
Chemical
Reg. No./Substance:
0/Cephalosporins; 38821-53-3/Cephradine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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