| Cephalometric findings in facioscapulohumeral muscular dystrophy patients with obstructive sleep apneas. | |
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MedLine Citation:
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PMID: 20174877 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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PURPOSES: The purposes of the study are: (1) to establish if cephalometry and upper airway examination may provide tools for detecting facioscapulohumeral (FSHD) patients at risk for obstructive sleep apnea syndrome (OSAS); and (2) to correlate cephalometry and otorhinolaryngologic evaluation with clinical and polysomnographic features of FHSD patients with OSAS. METHODS: Patients were 13 adults affected by genetically confirmed FSHD and OSAS, 11 men, with mean age 47.1 ± 12.8 years (range, 33-72 years). All underwent clinical evaluation, Manual Muscle Test, Clinical Severity Scale for FSHD, Epworth Sleepiness Scale, polysomnography, otorhinolaryngologic evaluation, and cephalometry. RESULTS: Cephalometric evidence of pharyngeal narrowing [posterior airways space (PAS) < 10 mm] was present in only one patient. The mandibular planus and hyoid (MP-H) distance ranged from 6.5 to 33.1 mm (mean, 17.5 ± 7.8 mm). The mean length of soft palate (PNS-P) was 31.9 ± 4.8 mm (range, 22.2 to 39.7 mm). No patient presented an ANB angle > 7°. There was no significant correlation between cephalometric measures, clinical scores, and PSG indexes. PAS and MP-H were not related to the severity of the disease. CONCLUSIONS: Upper airway morphological evaluation is of poor utility in the clinical assessment of FSHD patients and do not allow to predict the occurrence of sleep-related upper airway obstruction. This suggests that the pathogenesis of OSAS in FSHD is dependent on the muscular impairment, rather than to the anatomy of upper airways. |
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Authors:
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Giacomo Della Marca; Francesca Pantanali; Roberto Frusciante; Emanuele Scarano; Alessandro Cianfoni; Lea Calò; Serena Dittoni; Catello Vollono; Anna Losurdo; Elisa Testani; Salvatore Colicchio; Valentina Gnoni; Elisabetta Iannaccone; Benedetto Farina; Tommaso Pirronti; Pietro A Tonali; Enzo Ricci |
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Publication Detail:
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Type: Journal Article Date: 2010-02-20 |
Journal Detail:
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Title: Sleep & breathing = Schlaf & Atmung Volume: 15 ISSN: 1522-1709 ISO Abbreviation: Sleep Breath Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-05-20 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9804161 Medline TA: Sleep Breath Country: Germany |
Other Details:
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Languages: eng Pagination: 99-106 Citation Subset: IM |
Affiliation:
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Department of Neurosciences, Catholic University, Rome, Italy, dellamarca@rm.unicatt.it. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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