Document Detail


Cephalic phase pancreatic polypeptide responses to liquid and solid stimuli in humans.
MedLine Citation:
PMID:  19944113     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The hormone, pancreatic polypeptide (PP) is postulated to be involved in body weight regulation. PP release is dependent on vagal activation and is a marker of vagal efferent activity. Because vagal activity plays a role in glucose homeostasis, elucidating the conditions of activation has important implications for nutrient metabolism. In humans, modified sham-feeding is known to elicit vagally-mediated hormonal responses. We present results of 3 studies in which healthy human subjects tasted various stimuli including sweet and salty liquids, unflavored and flavored gum and mixed nutrient foods flavored with either sweet or salt and rendered palatable or unpalatable. We examined the effects of these stimuli on PP levels relative to fasting. We found that liquids flavored with either glucose or salt, did not elicit an increase in PP levels greater than fasting. Similarly, chewing gum, whether unflavored or flavored with a non-nutritive sweetener or the sweetener paired with a mint flavor, did not significantly increase PP levels. In contrast, when subjects tasted mixed nutrient foods, these reliably elicited increases in PP levels at 4 min post-stimulus (sweet palatable, p<0.002; sweet unpalatable, p<0.001; salty, palatable, p<0.05, salty unpalatable, p<0.05). The magnitude of release was influenced by the flavor, i.e. a sweet palatable stimulus (320.1+/-93.7 pg/ml/30 min) elicited the greatest increase in PP compared with a salty palatable stimulus (142.4+/-88.7 pg/ml/30 min; p<0.05). These data suggest that liquids and chewing gum do not provide adequate stimulation for vagal efferent activation in humans and that mixed nutrient foods are the optimal stimuli.
Authors:
Karen L Teff
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2009-11-26
Journal Detail:
Title:  Physiology & behavior     Volume:  99     ISSN:  1873-507X     ISO Abbreviation:  Physiol. Behav.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-01-29     Completed Date:  2010-04-22     Revised Date:  2014-09-14    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  United States    
Other Details:
Languages:  eng     Pagination:  317-23     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2009 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adult
Beverages*
Blood Glucose
Brain / physiology
Chewing Gum
Eating / physiology
Female
Food*
Humans
Insulin / blood
Male
Pancreatic Polypeptide / blood*
Taste / physiology
Vagus Nerve / physiology*
Grant Support
ID/Acronym/Agency:
DK-19525/DK/NIDDK NIH HHS; DK58003-07/DK/NIDDK NIH HHS; R01 DK058003/DK/NIDDK NIH HHS; R01 DK058003-07/DK/NIDDK NIH HHS; UL1 RR024134/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Chewing Gum; 0/Insulin; 59763-91-6/Pancreatic Polypeptide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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