Document Detail

Cephalexin-related nephropathy.
MedLine Citation:
PMID:  1242194     Owner:  NLM     Status:  MEDLINE    
Hematuria and eosinophilia developed in two patients being treated for bacterial endocarditis with 20 or 24 gm/day of cephalexin given orally together with probenecid (Benemid). One patient had a concurrent transient increase in serum creatinine; both patients had a history of penicillin allergy and had previously received cephalexin intravenously. All abnormalities promptly remitted following discontinuation of therapy.
S Verma; E Kieff
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  JAMA     Volume:  234     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1975-12-29     Completed Date:  1975-12-29     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  618-9     Citation Subset:  AIM; IM    
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MeSH Terms
Administration, Oral
Cephalexin / administration & dosage,  adverse effects*,  therapeutic use
Drug Hypersensitivity
Endocarditis / drug therapy
Eosinophilia / chemically induced*,  immunology
Hematuria / chemically induced*,  immunology
Kidney Diseases / chemically induced*
Probenecid / administration & dosage,  therapeutic use
Reg. No./Substance:
OBN7UDS42Y/Cephalexin; PO572Z7917/Probenecid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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