Document Detail


Centrosomes, chromosome instability (CIN) and aneuploidy.
MedLine Citation:
PMID:  23127609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Each time a cell divides its chromosome content must be equally segregated into the two daughter cells. This critical process is mediated by a complex microtubule based apparatus, the mitotic spindle. In most animal cells the centrosomes contribute to the formation and the proper function of the mitotic spindle by anchoring and nucleating microtubules and by establishing its functional bipolar organization. Aberrant expression of proteins involved in centrosome biogenesis can drive centrosome dysfunction or abnormal centrosome number, leading ultimately to improper mitotic spindle formation and chromosome missegregation. Here we review recent work focusing on the importance of the centrosome for mitotic spindle formation and the relation between the centrosome status and the mechanisms controlling faithful chromosome inheritance.
Authors:
Benjamin D Vitre; Don W Cleveland
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-11-03
Journal Detail:
Title:  Current opinion in cell biology     Volume:  24     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2014-02-21     Revised Date:  2014-04-18    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  809-15     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Aneuploidy*
Animals
Cell Cycle
Cell Proliferation
Centrosome / metabolism*,  pathology
Chromosomal Instability*
Humans
Microtubules / metabolism
Spindle Apparatus / metabolism
Tumor Suppressor Protein p53 / metabolism
Grant Support
ID/Acronym/Agency:
GM29513/GM/NIGMS NIH HHS; R01 GM029513/GM/NIGMS NIH HHS; R37 GM029513/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Tumor Suppressor Protein p53
Comments/Corrections

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