Document Detail

Centrosome size is controlled by centriolar SAS-4.
MedLine Citation:
PMID:  12837604     Owner:  NLM     Status:  MEDLINE    
The centrosome consists of a pair of centrioles and a surrounding matrix of pericentriolar material that anchors microtubule nucleation sites and consequently determines the number and organization of microtubules in interphase and mitotic cells. Recent studies utilizing a functional genomics approach in the nematode worm Caenorhabditis elegans and sophisticated light and electron microscopy techniques provide new insight into how centrioles act as centrosomal organizers and use a centriolar structural element to dictate centrosome size by defining their capacity to recruit pericentriolar material.
Jeffrey L Salisbury
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Trends in cell biology     Volume:  13     ISSN:  0962-8924     ISO Abbreviation:  Trends Cell Biol.     Publication Date:  2003 Jul 
Date Detail:
Created Date:  2003-07-02     Completed Date:  2003-09-05     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9200566     Medline TA:  Trends Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  340-3     Citation Subset:  IM    
Tumor Biology Program, Mayo Clinic, Rochester, MN 55905, USA.
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MeSH Terms
Caenorhabditis elegans / cytology,  embryology,  metabolism
Caenorhabditis elegans Proteins / metabolism*
Cell Division / physiology*
Centrioles / metabolism*,  ultrastructure
Centrosome / metabolism*,  ultrastructure
Embryo, Nonmammalian / cytology,  embryology,  metabolism
Eukaryotic Cells / metabolism*,  ultrastructure
Microtubule-Organizing Center / metabolism*,  ultrastructure
Reg. No./Substance:
0/Caenorhabditis elegans Proteins; 0/SAS-4 protein, C elegans

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