Document Detail


Centrosome asymmetry and inheritance during animal development.
MedLine Citation:
PMID:  22683192     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The centrosome is a subcellular organelle that is responsible for the majority of microtubule organization. Through this ability, the centrosome is involved in cell division, migration, and polarization. Recent studies have revealed intriguing asymmetries between mother and daughter centrioles as well as between mother and daughter centrosomes, and the involvement of such asymmetries in multiple cellular and developmental processes. This review aims to summarize recent discoveries on such asymmetries in centrioles/centrosomes and the potential implication of their inheritance patterns during cell division and development.
Authors:
Laurence Pelletier; Yukiko M Yamashita
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2012-06-08
Journal Detail:
Title:  Current opinion in cell biology     Volume:  24     ISSN:  1879-0410     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-22     Completed Date:  2013-04-05     Revised Date:  2013-08-14    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  541-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier Ltd. All rights reserved.
Affiliation:
Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, Canada. pelletier@lunenfeld.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Asymmetric Cell Division
Centrioles / metabolism
Centrosome / metabolism,  physiology*
Growth and Development*
Microtubules / metabolism
Stem Cells / cytology
Grant Support
ID/Acronym/Agency:
R01GM086481/GM/NIGMS NIH HHS; R21 HD067692/HD/NICHD NIH HHS; R21HD067692/HD/NICHD NIH HHS
Comments/Corrections

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