Document Detail

Centrosome amplification can initiate tumorigenesis in flies.
MedLine Citation:
PMID:  18555779     Owner:  NLM     Status:  MEDLINE    
Centrosome amplification is a common feature of many cancer cells, and it has been previously proposed that centrosome amplification can drive genetic instability and so tumorigenesis. To test this hypothesis, we generated Drosophila lines that have extra centrosomes in approximately 60% of their somatic cells. Many cells with extra centrosomes initially form multipolar spindles, but these spindles ultimately become bipolar. This requires a delay in mitosis that is mediated by the spindle assembly checkpoint (SAC). As a result of this delay, there is no dramatic increase in genetic instability in flies with extra centrosomes, and these flies maintain a stable diploid genome over many generations. The asymmetric division of the larval neural stem cells, however, is compromised in the presence of extra centrosomes, and larval brain cells with extra centrosomes can generate metastatic tumors when transplanted into the abdomens of wild-type hosts. Thus, centrosome amplification can initiate tumorigenesis in flies.
Renata Basto; Kathrin Brunk; Tatiana Vinadogrova; Nina Peel; Anna Franz; Alexey Khodjakov; Jordan W Raff
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cell     Volume:  133     ISSN:  1097-4172     ISO Abbreviation:  Cell     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-07-03     Revised Date:  2014-09-16    
Medline Journal Info:
Nlm Unique ID:  0413066     Medline TA:  Cell     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1032-42     Citation Subset:  IM    
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MeSH Terms
Animals, Genetically Modified
Centrosome / metabolism*
Drosophila Proteins / genetics,  metabolism
Drosophila melanogaster / cytology*,  genetics*
Green Fluorescent Proteins / metabolism
Kinesin / metabolism
Larva / cytology,  genetics
Protein-Serine-Threonine Kinases
Spindle Apparatus
Grant Support
R01 GM059363/GM/NIGMS NIH HHS; R01 GM059363-10/GM/NIGMS NIH HHS; //Cancer Research UK; //Wellcome Trust
Reg. No./Substance:
0/Drosophila Proteins; 0/ncd protein, Drosophila; 147336-22-9/Green Fluorescent Proteins; EC Kinases; EC protein, Drosophila; EC 3.6.1.-/Kinesin
Comment In:
Cell. 2008 Aug 22;134(4):572-5   [PMID:  18724931 ]

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