| Centriolar mechanisms of differentiation and replicative aging of higher animal cells. | |
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MedLine Citation:
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PMID: 16336191 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The centrosome (centriole) and the cytoskeleton produced by it are structures, which probably determine differentiation, morphogenesis, and switching on the mechanism of replicative aging in all somatic cells of multicellular animals. The mechanism of such programming of the events seems to include cytoskeleton influences and small RNAs related to the centrosome. 1) If these functions are really related with centrioles, the multicellular organism's cells which: a) initially lack centrioles (e.g., higher plant cells and also zygote and early blastomeres of some animals) or cytoskeleton (e.g., embryonic stem cells); or b) generate centrioles de novo (e.g., zygote and early blastomeres of some animals), will be totipotent and lack replicative aging. Consequently, the absence (constant or temporary) of the structure determining the counting of divisions also means the absence of counting of differentiation processes. 2) Although a particular damage to centrioles or cytoskeleton (e.g., in tumor cells) fails to make the cells totipotent (because the morphogenetic status of these cells, as differentiated from that of totipotent ones, is not zero), but such a transformation can suppress the initiation of the aging mechanism induced by these structures and, thus, make such cells replicatively "immortal". |
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Authors:
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J V Tkemaladze; K N Chichinadze |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemistry. Biokhimii?a Volume: 70 ISSN: 0006-2979 ISO Abbreviation: Biochemistry Mosc. Publication Date: 2005 Nov |
Date Detail:
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Created Date: 2005-12-12 Completed Date: 2006-06-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376536 Medline TA: Biochemistry (Mosc) Country: United States |
Other Details:
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Languages: eng Pagination: 1288-303 Citation Subset: IM |
Affiliation:
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Georgian Systemic Research Center, Tbilisi, 0160, Georgia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Aging / physiology* Cell Differentiation / physiology* Cell Division / physiology* Centrioles / physiology* Cytoplasm |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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