| Centrally and peripherally administered ghrelin potently inhibits water intake in rats. | |
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MedLine Citation:
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PMID: 17255209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ghrelin is known as a potent orexigenic hormone through its action on the brain. In this study, we examined the effects of intracerebroventricular (icv) and iv injection of ghrelin on water intake, food intake, and urine volume in rats deprived of water for 24 h. Water intake that occurred after water deprivation was significantly inhibited by icv injection of ghrelin (0.1, 1, and 10 nmol/rat) in a dose-related manner, although food intake was stimulated by the hormone. The antidipsogenic effect was as potent as the orexigenic effect. Similarly, water intake was inhibited, whereas food intake was stimulated dose dependently after iv injection of ghrelin (0.1, 1, and 10 nmol/kg). The inhibition of drinking was comparable with, or even more potent than, atrial natriuretic peptide (ANP), an established antidipsogenic hormone, when administered icv, although the antidipsogenic effect lasted longer. ANP had no effect on food intake. Urine volume decreased dose relatedly after icv injection of ghrelin but not by ANP. Intravenous injection of ghrelin had no effect on urine volume. Because drinking usually occurs with feeding, food was withdrawn to remove the prandial drinking. Then the antidipsogenic effect of ghrelin became more potent than that of ANP and continued longer than when food was available. Expression of Fos was increased in the area postrema and the nucleus of the tractus solitarius by using immunohistochemistry after icv and iv injection of ghrelin. The present study convincingly showed that ghrelin is a potent antidisogenic peptide in rats. |
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Authors:
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Hirofumi Hashimoto; Hiroaki Fujihara; Makoto Kawasaki; Takeshi Saito; Minori Shibata; Hiroki Otsubo; Yoshio Takei; Yoichi Ueta |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2007-01-25 |
Journal Detail:
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Title: Endocrinology Volume: 148 ISSN: 0013-7227 ISO Abbreviation: Endocrinology Publication Date: 2007 Apr |
Date Detail:
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Created Date: 2007-03-19 Completed Date: 2007-04-24 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0375040 Medline TA: Endocrinology Country: United States |
Other Details:
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Languages: eng Pagination: 1638-47 Citation Subset: AIM; IM |
Affiliation:
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Department of Physiology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Brain / drug effects, metabolism Dose-Response Relationship, Drug Drinking / drug effects* Eating / drug effects Ghrelin Injections, Intravenous Injections, Intraventricular Male Peptide Hormones / administration & dosage* Proto-Oncogene Proteins c-fos / metabolism Rats Rats, Wistar Time Factors Urine |
| Chemical | |
Reg. No./Substance:
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0/Ghrelin; 0/Peptide Hormones; 0/Proto-Oncogene Proteins c-fos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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