Document Detail

Centrally injected kisspeptin reduces food intake by increasing meal intervals in mice.
MedLine Citation:
PMID:  21386700     Owner:  NLM     Status:  MEDLINE    
Kisspeptin is distributed not only in brain areas for regulating reproduction but also in nuclei involved in feeding control. Whether kisspeptin alters food intake is unknown in mice. We examined how kisspeptin-10 influences feeding after intracerebroventricular injection in mice using automated monitoring. Kisspeptin-10 (0.3, 1, and 3 μg/mouse) dose-dependently inhibited the feeding response to an overnight fast by 50, 95, and 90% respectively, during the 2-3 h period postinjection. The 1μg/mouse dose reduced the 4-h cumulative food intake by 28% whereas intraperitoneal injection (10 μg/mouse) did not. The decreased 4-h food intake was due to reduced meal frequency (-45%/4 h), whereas meal size and gastric emptying were not altered. These data suggest that kisspeptin may be a negative central regulator of feeding by increasing satiety.
Andreas Stengel; Lixin Wang; Miriam Goebel-Stengel; Yvette Taché
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Neuroreport     Volume:  22     ISSN:  1473-558X     ISO Abbreviation:  Neuroreport     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-03-09     Completed Date:  2011-10-03     Revised Date:  2013-06-30    
Medline Journal Info:
Nlm Unique ID:  9100935     Medline TA:  Neuroreport     Country:  England    
Other Details:
Languages:  eng     Pagination:  253-7     Citation Subset:  IM    
CURE/Digestive Diseases Research Center, Center for Neurobiology of Stress, Department of Medicine, Digestive Diseases Division at the University of California Los Angeles, VA Greater Los Angeles Health Care System, California, USA.
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MeSH Terms
Brain / drug effects,  physiology*
Eating / drug effects,  physiology*
Feeding Behavior / drug effects,  physiology*
Injections, Intraventricular
Mice, Inbred C57BL
Tumor Suppressor Proteins / administration & dosage,  metabolism*
Grant Support
DK-41301/DK/NIDDK NIH HHS; P30 DK041301-13/DK/NIDDK NIH HHS; R01 DK-33061/DK/NIDDK NIH HHS; R01 DK033061-26/DK/NIDDK NIH HHS; R37 DK033061-18/DK/NIDDK NIH HHS; R37 DK033061-18S1/DK/NIDDK NIH HHS
Reg. No./Substance:
0/Kiss1 protein, mouse; 0/Kisspeptins; 0/Tumor Suppressor Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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