Document Detail

Centrally-induced vasopressor responses to carbachol are augmented in DOCA-salt hypertensive rats.
MedLine Citation:
PMID:  6697339     Owner:  NLM     Status:  MEDLINE    
Increased sympathetic nervous system activity and vasopressin release has been demonstrated in established DOCA-salt hypertension in the rat. To determine the importance of these mechanisms in centrally-mediated pressor responses in this model of hypertension, both awake rats and rats anaesthetised with urethane were given intracerebroventricular injections of carbachol. The systolic blood pressure after implanting a silicon rubber mould containing DOCA, and with subsequent substitution of 1% saline in tap water, increased from 112 +/- 3 mmHg to a stable 188 +/- 7 mmHg by the end of 4 weeks, measured using a tail-cuff method. The blood pressure consistently became elevated when carbachol was injected into the cerebral ventricles of awake rats. Of the three groups of normotensive rats (NTR), sham-operated rats (SHAM) and DOCA-salt hypertensive rats (DOCA), the magnitude of the pressor phase was largest in the DOCA rats. The heart rate in all three groups of rats decreased similarly. When the rats were later anaesthetised with urethane to allow recording of abdominal sympathetic nerve activity, the carbachol injections caused biphasic blood pressure responses and sympathetic nerve discharge consisting of initial vasodepression and sympathetic nerve inhibition of short duration. This was followed by a sustained pressor phase accompanied by a corresponding increase in sympathetic nerve activity. The magnitude of the pressor response was again larger in the DOCA than in the SHAM rats. Spinal section abolished the initial depressor phase but did not much affect the sustained pressor phase.(ABSTRACT TRUNCATED AT 250 WORDS)
H Takahashi; A Inoue; K Takeda; H Okajima; S Sasaki; I Iyoda; M Yoshimura; M Nakagawa; H Ijichi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cardiovascular research     Volume:  18     ISSN:  0008-6363     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  1984 Feb 
Date Detail:
Created Date:  1984-04-26     Completed Date:  1984-04-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  126-32     Citation Subset:  IM    
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MeSH Terms
Action Potentials
Blood Pressure / drug effects*
Carbachol / pharmacology*
Heart Rate / drug effects
Hypertension, Renal / chemically induced,  physiopathology*
Injections, Intraventricular
Rats, Inbred Strains
Sympathetic Nervous System / physiopathology
Time Factors
Reg. No./Substance:
51-83-2/Carbachol; 64-85-7/Desoxycorticosterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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