| Centrally coinjected galanin and a 5-HT1A agonist act synergistically to produce vasodepressor responses in the rat. | |
| | |
MedLine Citation:
|
PMID: 1725157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The present study was undertaken to evaluate the possible functional implications of the previously demonstrated in vitro interactions between galanin and 5-HT1A receptors. To this end we analysed the interactions between galanin and the 5-HT1A receptor agonist 8-OH-2-(di-n-propylamino)-tetralin (8-OH-DPAT) in central cardiovascular regulation. 8-OH-DPAT given intracisternally (i.c.) produced a dose-dependent reduction of blood pressure, the peak action being 32% at 10 nmol of 8-OH-DPAT. Heart rate and respiration rate were not affected. The vasodepressor action of 8-OH-DPAT was counteracted by the 5-HT1A receptor antagonist 1-(2-methoxyphenyl)-4-[4-(2-phthalimido)butyl]piperazine (NAN-190). A threshold dose (1 nmol) of galanin given i.c. was shown to enhance the vasodepressor effect of both an ED50 dose and a threshold dose of 8-OH-DPAT. Quantitative receptor autoradiography showed that the IC50 values for [125I]galanin binding sites were reduced in the presence of 8-OH-DPAT (10 nM) by approximately 40% in the dorsal region of the nucleus of the solitary tract, the area postrema, and the raphe pallidus and obscurus nuclei. Galanin (10 nM) also significantly increased the IC50 value for [3H]8-OH-DPAT binding sites within the nucleus of the solitary tract. The results provide evidence for a synergistic interaction between 8-OH-DPAT and galanin in cardiovascular regulation after their central administration, an interaction possibly related to the ability of 8-OH-DPAT to enhance the affinity of the galanin receptor within regions of the medulla oblongata involved in cardiovascular control. |
| | |
Authors:
|
P B Hedlund; J A Aguirre; J A Narvaez; K Fuxe |
Related Documents
:
|
14638487 - 5ht1a serotonin receptor agonists inhibit plasmodium falciparum by blocking a membrane ... 15193537 - Way100635 and female rat lordosis behavior. 15381287 - 5-hydroxytryptamine1a-like receptor activation in the bed nucleus of the stria terminal... 12135537 - Region-dependent effects of flibanserin and buspirone on adenylyl cyclase activity in t... 7871047 - Chronic treatment with the d1 receptor antagonist, sch 23390, and the d2 receptor antag... 18378267 - Modulation of tonic immobility in guinea pig pag by homocysteic acid, a glutamate agonist. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: European journal of pharmacology Volume: 204 ISSN: 0014-2999 ISO Abbreviation: Eur. J. Pharmacol. Publication Date: 1991 Oct |
Date Detail:
|
Created Date: 1992-05-06 Completed Date: 1992-05-06 Revised Date: 2006-11-15 |
Medline Journal Info:
|
Nlm Unique ID: 1254354 Medline TA: Eur J Pharmacol Country: NETHERLANDS |
Other Details:
|
Languages: eng Pagination: 87-95 Citation Subset: IM |
Affiliation:
|
Department of Histology and Neurobiology, Karolinska Institutet, Stockholm, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
8-Hydroxy-2-(di-n-propylamino)tetralin Animals Autoradiography Blood Pressure / drug effects* Cardiovascular System / drug effects Dose-Response Relationship, Drug Drug Synergism Galanin Male Medulla Oblongata / ultrastructure Peptides / metabolism, pharmacology* Rats Rats, Inbred Strains Receptors, Galanin Receptors, Gastrointestinal Hormone / metabolism Receptors, Serotonin / physiology* Tetrahydronaphthalenes / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Peptides; 0/Receptors, Galanin; 0/Receptors, Gastrointestinal Hormone; 0/Receptors, Serotonin; 0/Tetrahydronaphthalenes; 78950-78-4/8-Hydroxy-2-(di-n-propylamino)tetralin; 88813-36-9/Galanin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Evidence for protein kinase C modulation of the ciliary muscle response to carbachol and desensitiza...
Next Document: Metastatic prostatic adenocarcinoma-diagnosed by bronchoalveolar lavage and tumour marker determinat...