Document Detail

Centrally bradykinin B2-receptor-induced hypertensive and positive chronotropic effects are mediated via activation of the sympathetic nervous system.
MedLine Citation:
PMID:  10489103     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The presence of bradykinin B2 receptors in the cardiovascular regulatory centres of the brain indicates that increase in mean arterial pressure (MAP) and heart rate after intracerebroventricular (i.c.v.) injections of bradykinin is mediated via stimulation of sympathetic nervous system. METHODS: Adult Wistar- Kyoto (WKY) rats were instrumented chronically with an i.c.v. cannula, and the catheters were placed into the femoral artery and vein. Increasing doses of bradykinin (1 -300 pmol) were given i.c.v. and (i) MAP and heart rate, (ii) plasma dopamine, noradrenaline and adrenaline, and (iii) plasma arginine vasopressin (AVP) levels were determined. In addition, following blockade of peripheral alpha1 -adrenoceptors with prazosin (50 and 250 microg/kg i.v.) beta1-adrenoceptors with atenolol (10 mg/kg i.v.) or V1 -receptors with TMe-AVP (Manning compound) (10 microg/kg i.c.v. and 100 microg/kg i.v.) the effects of bradykinin (100 pmol i.c.v.) on MAP and heart rate were determined. RESULTS: Bradykinin increased MAP and heart rate dose-dependently. The pressor effects of 100 pmol bradykinin i.c.v. were completely blocked by pretreatment with the specific B2 receptor antagonist Hoe 140 (3 pmol, i.c.v.). There was no change in plasma dopamine, noradrenaline, adrenaline or AVP levels after increasing doses of bradykinin. However, peripheral blockade of alpha1- and beta1-adrenoceptors reduced the bradykinin-induced increase in MAP and heart rate, whereas central and peripheral V1 receptor blockade did not alter the cardiovascular responses to i.c.v. bradykinin. CONCLUSION: Our data suggest that the hypertensive and positive chronotropic effects induced by i.c.v. bradykinin are due to stimulation of sympathoneuronal rather than sympathoadrenal pathway in vivo.
F Qadri; L Bäurle; W Häuser; W Rascher; P Dominiak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of hypertension     Volume:  17     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-12-09     Completed Date:  1999-12-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  1265-71     Citation Subset:  IM    
Institute of Experimental and Clinical Pharmacology and Toxicology, Medical University of Lübeck, Germany.
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MeSH Terms
Adrenergic beta-Antagonists / pharmacology
Arginine Vasopressin / blood
Blood Pressure / drug effects*,  physiology
Bradykinin / analogs & derivatives,  pharmacology
Catecholamines / blood
Dose-Response Relationship, Drug
Heart Rate / drug effects*,  physiology
Injections, Intraventricular
Rats, Inbred WKY
Receptor, Bradykinin B2
Receptors, Adrenergic, alpha-1 / antagonists & inhibitors
Receptors, Adrenergic, beta-1 / antagonists & inhibitors
Receptors, Bradykinin / antagonists & inhibitors,  metabolism,  physiology*
Receptors, Vasopressin / antagonists & inhibitors
Stimulation, Chemical
Sympathetic Nervous System / drug effects
Reg. No./Substance:
0/Adrenergic beta-Antagonists; 0/Catecholamines; 0/Receptor, Bradykinin B2; 0/Receptors, Adrenergic, alpha-1; 0/Receptors, Adrenergic, beta-1; 0/Receptors, Bradykinin; 0/Receptors, Vasopressin; 113-79-1/Arginine Vasopressin; 130308-48-4/icatibant; 58-82-2/Bradykinin

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