Document Detail

Centrally administered urocortin 3 inhibits food intake and gastric emptying in mice.
MedLine Citation:
PMID:  21061090     Owner:  NLM     Status:  In-Process    
Urocortin 3 (Ucn3) is recognized as a member of the corticotropin-releasing factor (CRF) family, which plays an important role in regulating food intake. We investigated the effects of centrally administered Ucn3 on food intake and gastric emptying in mice. Intracerebroventricular (ICV)administration of Ucn3 (0.1–1 nmol per mouse) decreased food intake in a dose-dependent manner. The inhibitory effect of Ucn3 on food intake was less potent than that of centrally administered CRF and Urocortin 1. ICV administration of Ucn3 (0.1–1 nmol per mouse) decreased the gastric emptying rate in a dose-dependent manner. Ucn3 decreased food intake in high-fat diet-fed obese mice as well as in lean mice. These results indicated that Ucn3 influences feeding behavior and gut motility, and may be a promising therapeutic target in the treatment of eating and functional gastrointestinal disorders.
Miharu Ushikai; Akihiro Asakawa; Takeo Sakoguchi; Chie Tanaka; Akio Inui
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Endocrine     Volume:  39     ISSN:  1559-0100     ISO Abbreviation:  Endocrine     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-07-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434444     Medline TA:  Endocrine     Country:  United States    
Other Details:
Languages:  eng     Pagination:  113-7     Citation Subset:  IM    
Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences,8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan.
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