Document Detail

Centrally administered thyrotropin-releasing hormone in the regulation of regional blood flow to brown adipose tissue in rats.
MedLine Citation:
PMID:  3137079     Owner:  NLM     Status:  MEDLINE    
The effects of thyrotropin-releasing hormone (TRH) administered via the lateral ventricle on the blood flow to the interscapular brown adipose tissue (IBAT) was studied in urethane anaesthetized rats. TRH in i.c.v. doses of 50 or 5 micrograms/kg produced a significant and transient decrease in IBAT blood flow. The effect of 5 micrograms/kg TRH was blocked by bilateral surgical denervation. TRH caused a comparable decrease in blood flow to both the innervated pad of unilaterally denervated rats and the intact pads of non-operated rats whereas no response to TRH was observed in the denervated pad. Adrenal demedullation partly inhibited but did not completely abolish the effect of TRH on IBAT blood flow and lessened the increase in serum adrenaline caused by TRH. The effect of TRH was dose dependently suppressed by pretreatment with prazosin 15 min prior to TRH. Yohimbine did not influence the effect of TRH on IBAT blood flow. Central administration of TRH affects the regional blood flow to IBAT and appears to interfere with neural mechanisms that involve mediation by the alpha 1-adrenoceptors on the vasculature. The effect is in part due to circulating adrenaline from the adrenal medulla.
Y Uchida; T Nomoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of pharmacology     Volume:  149     ISSN:  0014-2999     ISO Abbreviation:  Eur. J. Pharmacol.     Publication Date:  1988 May 
Date Detail:
Created Date:  1988-10-05     Completed Date:  1988-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1254354     Medline TA:  Eur J Pharmacol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  257-65     Citation Subset:  IM    
Department of Pharmacology, Tokyo Women's Medical College, Japan.
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MeSH Terms
Adipose Tissue, Brown / blood supply*
Adrenal Medulla / physiology
Blood Pressure / drug effects
Catecholamines / blood
Heart Rate / drug effects
Injections, Intraventricular
Prazosin / pharmacology
Rats, Inbred Strains
Regional Blood Flow / drug effects
Thyrotropin-Releasing Hormone / administration & dosage,  pharmacology*
Yohimbine / pharmacology
Reg. No./Substance:
0/Catecholamines; 146-48-5/Yohimbine; 19216-56-9/Prazosin; 24305-27-9/Thyrotropin-Releasing Hormone

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