Document Detail

Centrally administered galanin-like peptide modifies food intake in the rat: a comparison with galanin.
MedLine Citation:
PMID:  12421338     Owner:  NLM     Status:  MEDLINE    
Galanin-like peptide (GALP) is a recently identified neuropeptide that shares sequence homology with the orexigenic neuropeptide, galanin. In contrast to galanin, GALP is reported to bind preferentially to the galanin receptor 2 subtype (GalR2) compared to GalR1. The aim of this study was to determine the effect of GALP on feeding, body weight and core body temperature after central administration in rats compared to the effects of galanin. Intracerebroventricular (i.c.v.) injection of GALP (1 micro g-10 micro g) significantly stimulated feeding at 1 h in both satiated and fasted Sprague-Dawley rats. However, 24 h after GALP injection, body weight gain was significantly reduced and food intake was also usually decreased. In addition, i.c.v. GALP caused a dose-related increase in core body temperature, which lasted until 6-8 h after injection, and was reduced by peripheral administration of the cyclooxygenase inhibitor, flurbiprofen (1 mg/kg). Similar to GALP, i.c.v. injection of galanin (5 micro g) significantly increased feeding at 1 h in satiated rats. However, there was no difference in food intake and body weight at 24 h, and galanin only caused a transient rise in body temperature. Thus, similar to galanin, GALP has an acute orexigenic effect on feeding. However, GALP also has an anorectic action, which is apparent at a later time. Therefore, GALP has complex opposing actions on energy homeostasis.
C B Lawrence; F M-H Baudoin; S M Luckman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  14     ISSN:  0953-8194     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-07     Completed Date:  2003-01-03     Revised Date:  2014-10-14    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  853-60     Citation Subset:  IM    
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MeSH Terms
Cyclooxygenase Inhibitors / pharmacology
Dose-Response Relationship, Drug
Eating / drug effects*
Fasting / physiology
Flurbiprofen / pharmacology
Galanin / administration & dosage,  pharmacology
Galanin-Like Peptide
Injections, Intraventricular
Nerve Tissue Proteins / administration & dosage*,  pharmacology
Rats, Sprague-Dawley
Satiation / physiology
Grant Support
NEU15392//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
0/Cyclooxygenase Inhibitors; 0/Galanin-Like Peptide; 0/Nerve Tissue Proteins; 5GRO578KLP/Flurbiprofen; 88813-36-9/Galanin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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