| Centrally administered neuromedin S inhibits feeding behavior and gastroduodenal motility in mice. | |
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MedLine Citation:
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PMID: 20352600 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Neuromedin S (NMS) was recently identified as an endogenous ligand for the FM-4/TGR-1 receptor in the rat hypothalamus. No previous studies have examined the effect of NMS on gut motility. We examined the effects of intracerebroventricular administration of NMS on food intake in food-deprived and free-feeding mice, and on gastroduodenal motility by using a manometric method, and gastric emptying in mice. We found that NMS decreased food intake and the gastric emptying rate. It also disrupted the motor activity in the antrum and duodenum of conscious food-deprived mice. These results suggest that NMS influences gut motility as well as feeding behavior. |
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Authors:
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K Atsuchi; A Asakawa; M Ushikai; K Ataka; R Tanaka; I Kato; M Fujimiya; A Inui |
Publication Detail:
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Type: Journal Article Date: 2010-03-29 |
Journal Detail:
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Title: Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme Volume: 42 ISSN: 1439-4286 ISO Abbreviation: Horm. Metab. Res. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-10 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0177722 Medline TA: Horm Metab Res Country: Germany |
Other Details:
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Languages: eng Pagination: 535-8 Citation Subset: IM |
Copyright Information:
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Georg Thieme Verlag KG Stuttgart * New York. |
Affiliation:
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Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Japan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Duodenum / drug effects, physiology* Eating / drug effects Feeding Behavior / drug effects* Gastrointestinal Motility / drug effects* Injections, Intraventricular Male Mice Mice, Inbred C57BL Neuropeptides / administration & dosage* |
| Chemical | |
Reg. No./Substance:
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0/Neuropeptides; 0/neuromedin S |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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