Document Detail

Centrally administered neuromedin S inhibits feeding behavior and gastroduodenal motility in mice.
MedLine Citation:
PMID:  20352600     Owner:  NLM     Status:  MEDLINE    
Neuromedin S (NMS) was recently identified as an endogenous ligand for the FM-4/TGR-1 receptor in the rat hypothalamus. No previous studies have examined the effect of NMS on gut motility. We examined the effects of intracerebroventricular administration of NMS on food intake in food-deprived and free-feeding mice, and on gastroduodenal motility by using a manometric method, and gastric emptying in mice. We found that NMS decreased food intake and the gastric emptying rate. It also disrupted the motor activity in the antrum and duodenum of conscious food-deprived mice. These results suggest that NMS influences gut motility as well as feeding behavior.
K Atsuchi; A Asakawa; M Ushikai; K Ataka; R Tanaka; I Kato; M Fujimiya; A Inui
Publication Detail:
Type:  Journal Article     Date:  2010-03-29
Journal Detail:
Title:  Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et métabolisme     Volume:  42     ISSN:  1439-4286     ISO Abbreviation:  Horm. Metab. Res.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-06-10     Completed Date:  2010-09-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0177722     Medline TA:  Horm Metab Res     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  535-8     Citation Subset:  IM    
Copyright Information:
Georg Thieme Verlag KG Stuttgart * New York.
Department of Social and Behavioral Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Japan.
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MeSH Terms
Duodenum / drug effects,  physiology*
Eating / drug effects
Feeding Behavior / drug effects*
Gastrointestinal Motility / drug effects*
Injections, Intraventricular
Mice, Inbred C57BL
Neuropeptides / administration & dosage*
Reg. No./Substance:
0/Neuropeptides; 0/neuromedin S

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