Document Detail

Central versus peripheral arterial stiffness in association with coronary, cerebral and peripheral arterial disease.
MedLine Citation:
PMID:  20430390     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Although stiffness of central arteries is more preferentially associated with coronary artery disease (CAD) than that of peripheral arteries, less is known for cerebrovascular disease (CVD) and peripheral artery disease (PAD). We measured pulse wave velocity (PWV) in four arterial segments, and examined the relative changes in the four regional PWVs in patients with CAD, CVD or PAD.
METHODS: The 2798 subjects were selected from 3300 consecutive participants of our non-invasive vascular lab. 342 subjects had one or more pre-existing atherosclerotic diseases including 128 CAD (N=128), CVD (N=195) and PAD (N=83). PWVs were simultaneously measured using an automated pulse wave analyzer (model BP-203RPE, Colin) in the heart-femoral (hf, aorta), heart-carotid (hc), heart-brachial (hb), and femoral-ankle (fa) segments.
RESULTS: As compared to the subjects without atheroscletoric disease, those with CAD, CVD, or PAD showed higher levels of PWV in the four arterial segments, particularly in hfPWV. The relative increase in hfPWV remained significant after adjustment for age, sex, hypertension, pulse rate, smoking, diabetes mellistus, dyslipidemia, and chronic kidney disease.
CONCLUSION: This study indicates that the preferential increase in central arterial stiffness is found not only in CAD but CVD and PAD as well.
Shoko Tsuchikura; Tetsuo Shoji; Eiji Kimoto; Kayo Shinohara; Sawako Hatsuda; Hidenori Koyama; Masanori Emoto; Yoshiki Nishizawa
Publication Detail:
Type:  Journal Article     Date:  2010-04-09
Journal Detail:
Title:  Atherosclerosis     Volume:  211     ISSN:  1879-1484     ISO Abbreviation:  Atherosclerosis     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-08-02     Completed Date:  2010-12-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  480-5     Citation Subset:  IM    
Copyright Information:
Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, 1-4-3, Asahi-machi, Abeno-ku, Osaka 545-8585, Japan.
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MeSH Terms
Aorta / pathology
Atherosclerosis / pathology*
Blood Pressure
Cerebral Arterial Diseases / pathology*
Cerebrovascular Circulation
Coronary Artery Disease / pathology*
Middle Aged
Peripheral Arterial Disease / pathology*
Pulsatile Flow
Risk Assessment
Vascular Resistance*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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