| Central versus ambulatory blood pressure in the prediction of all-cause and cardiovascular mortalities. | |
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MedLine Citation:
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PMID: 21252703 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVES: Central systolic (SBP-C) and/or pulse pressure (PP-C) better predicts cardiovascular events than does peripheral blood pressure. The present study compared the prognostic significance of office central blood pressure with multiple measurements of out-of-office ambulatory peripheral blood pressure, with reference to office peripheral systolic (SBP-B) or pulse pressure (PP-B). METHODS: In a community-based population of 1014 healthy participants, SBP-C and PP-C were estimated using carotid tonometry, and 24-h systolic (SBP-24 h) and pulse pressure (PP-24 h) were obtained from 24-h ambulatory blood pressure monitoring. Associations of SBP-B, PP-B, SBP-C, PP-C, SBP-24 h, and PP-24 h with all-cause and cardiovascular mortalities over a median follow-up of 15 years were examined by Cox regression analysis. RESULTS: In multivariate analyses accounting for age, sex, BMI, smoking, fasting plasma glucose, and total cholesterol/high-density lipoprotein cholesterol ratio, only PP-C (hazard ratio 1.16, 95% confidence interval 1.01-1.32, per one standard deviation increment) was significantly predictive of all-cause mortality, whereas all but PP-B were significantly predictive of cardiovascular mortality. When SBP-B was simultaneously included in the models, SBP-24 h (2.01, 1.42-2.85) and SBP-C (1.71, 1.21-2.40) remained significantly predictive of cardiovascular mortality. When SBP-C was simultaneously included in the models, SBP-24 h (1.71, 1.16-2.52) remained significantly predictive of cardiovascular mortality. CONCLUSION: Office central blood pressure is more valuable than office peripheral blood pressure in the prediction of all-cause and cardiovascular mortalities. Out-of-office ambulatory peripheral blood pressure (SBP-24 h) may be superior to central blood pressure in the prediction of cardiovascular mortality, but PP-C may better predict all-cause mortality than SBP-24 h or PP-24 h. |
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Authors:
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Chi-Ming Huang; Kang-Ling Wang; Hao-Min Cheng; Shao-Yuan Chuang; Shih-Hsien Sung; Wen-Chung Yu; Chih-Tai Ting; Edward G Lakatta; Frank Cp Yin; Pesus Chou; Chen-Huan Chen |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of hypertension Volume: 29 ISSN: 1473-5598 ISO Abbreviation: J. Hypertens. Publication Date: 2011 Mar |
Date Detail:
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Created Date: 2011-02-14 Completed Date: 2011-06-16 Revised Date: 2012-09-20 |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: England |
Other Details:
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Languages: eng Pagination: 454-9 Citation Subset: IM |
Affiliation:
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Department of Medicine, Yuanshan Veterans Hospital, Yilan, Taiwan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Factors Aged Blood Pressure Determination* Blood Pressure Monitoring, Ambulatory* Cardiovascular Diseases / mortality* Cause of Death Female Humans Male Middle Aged |
| Grant Support | |
ID/Acronym/Agency:
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Z01 AG000856-07/AG/NIA NIH HHS |
| Comments/Corrections | |
Comment In:
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J Hypertens. 2011 Mar;29(3):430-3
[PMID:
21317722
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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