Document Detail

Central venous pressure in space.
MedLine Citation:
PMID:  8828643     Owner:  NLM     Status:  MEDLINE    
Gravity affects cardiac filling pressure and intravascular fluid distribution significantly. A major central fluid shift occurs when all hydrostatic gradients are abolished on entry into microgravity (microG). Understanding the dynamics of this shift requires continuous monitoring of cardiac filling pressure; central venous pressure (CVP) measurement is the only feasible means of accomplishing this. We directly measured CVP in three subjects: one aboard the Spacelab Life Sciences-1 space shuttle flight and two aboard the Spacelab Life Sciences-2 space shuttle flight. Continuous CVP measurements, with a 4-Fr catheter, began 4 h before launch and continued into microG. Mean CVP was 8.4 cmH2O seated before flight, 15.0 cmH2O in the supine legs-elevated posture in the shuttle, and 2.5 cmH2O after 10 min in microG. Although CVP decreased, the left ventricular end-diastolic dimension measured by echocardiography increased from a mean of 4.60 cm supine preflight to 4.97 cm within 48 h in microG. These data are consistent with increased cardiac filling early in microG despite a fall in CVP, suggesting that the relationship between CVP and actual transmural left ventricular filling pressure is altered in microG.
J C Buckey; F A Gaffney; L D Lane; B D Levine; D E Watenpaugh; S J Wright; C W Yancy; D M Meyer; C G Blomqvist
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  81     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-18     Completed Date:  1996-12-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  19-25     Citation Subset:  IM; S    
Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas 75235-9034, USA.
Space Flight Mission:
Flight Experiment; STS-40 Shuttle Project; STS-58 Shuttle Project; manned; short duration
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MeSH Terms
Blood Pressure / physiology
Catheterization, Central Venous
Central Venous Pressure / physiology*
Fluid Shifts / physiology
Gravity Suits
Heart / physiology
Heart Rate / physiology
Middle Aged
Posture / physiology
Space Flight*
Weightlessness / adverse effects
F A Gaffney / Vanderbilt U, Nashville, TN; C G Blomqvist / U TX Southwestern Med Ctr, Dallas

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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