Document Detail

Central venous pressure in humans during microgravity.
MedLine Citation:
PMID:  8828692     Owner:  NLM     Status:  MEDLINE    
Based on the results of head-down simulation studies and the results of parabolic flights, the hypothesis was tested that central venous pressure (CVP) in humans increases during microgravity (weightlessness) compared with during the ground-based supine position. CVP was recorded with an intravascular pressure transducer in seven healthy humans during short (20-s) periods of microgravity created by parabolic-flight maneuvers and in one astronaut before, during, and up to 3 h after launch of the Spacelab D-2 mission (Space Transport System-55). When the subjects were supine during the parabolic maneuver, CVP decreased during microgravity from 6.5 +/- 1.3 to 5.0 +/- 1.4 mmHg (P < 0.05). during the Spacelab D-2 mission, CVP was 6.2 mmHg during the initial minutes of microgravity, which was very similar to the value of 6.5 mmHg in the supine position 3.5 h before launch of the space shuttle. During the subsequent 3 h of weightlessness, CVP during rest varied between 2.0 and 6.2 mmHg. We conclude that CVP during short (20-s) and longer (3-h) periods of microgravity is close to or below that of the supine position on the ground.
N Foldager; T A Andersen; F B Jessen; P Ellegaard; C Stadeager; R Videbaek; P Norsk
Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  81     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  1996 Jul 
Date Detail:
Created Date:  1996-12-18     Completed Date:  1996-12-18     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  408-12     Citation Subset:  IM; S    
Danish Aerospace Medical Centre of Research, Rigshospitalet, Copenhagen, Denmark.
Space Flight Mission:
Flight Experiment; Parabolic Flight; STS-55 Shuttle Project; manned; short duration
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MeSH Terms
Central Venous Pressure / physiology*
Heart Rate / physiology
Middle Aged
Space Flight
Supine Position / physiology
Weightlessness / adverse effects*
Weightlessness Simulation

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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