Document Detail

Central venous and bladder pressure reflect transdiaphragmatic pressure during pressure support ventilation.
MedLine Citation:
PMID:  11834669     Owner:  NLM     Status:  MEDLINE    
STUDY OBJECTIVES: To determine whether the change in bladder pressure (Pblad) and central venous pressure (Pcvp) may reflect the changes in esophageal pressure (Pes) and gastric pressure (Pgas) when inspiratory pressure support (IPS) is altered. DESIGN: Prospective clinical study. SETTING: The ICUs of a teaching hospital. PATIENTS: Ten patients currently receiving IPS ventilation via a tracheostomy or an endotracheal tube who already had bladder and central venous catheters in situ. MEASUREMENTS AND RESULTS: Airway pressure, Pes, Pgas, Pcvp, Pblad, and flow were measured at the original IPS setting. IPS then was reduced by 5-cm H(2)O increments until IPS was zero or was at the minimum pressure that could be tolerated by each patient. At each level of IPS, pressures and flow were measured at steady-state breathing. The maximum pressure difference for each pressure during inspiration was calculated. We found that the Delta Pblad correlated closely with the Delta Pgas (r = 0.904) and that the Delta Pes correlated with the Delta Pcvp (r = 0.951). When the Delta Pcvp - Delta Pblad was compared with the transdiaphragmatic pressure for each patient as the IPS was altered, the correlation coefficients varied from 0.952 to 0.999. CONCLUSION: Although absolute values for the Delta Pcvp during mechanical ventilation do not always reflect the Delta Pes, useful information can be obtained from this route. In individual patients, the two sites of measurement followed each other when IPS was changed, enabling a bedside assessment of the response to reducing respiratory support.
Sarah Chieveley-Williams; Lila Dinner; Anna Puddicombe; Debbie Field; A T Lovell; John C Goldstone
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Chest     Volume:  121     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-08     Completed Date:  2002-03-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  533-8     Citation Subset:  AIM; IM    
Department of Anesthesia, University College London Medical School, London, UK.
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MeSH Terms
Central Venous Pressure*
Diaphragm / physiology*
Middle Aged
Respiration, Artificial*
Urinary Bladder / physiology*
Comment In:
Chest. 2002 Feb;121(2):324-6   [PMID:  11834637 ]

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