Document Detail

Central venous-arterial carbon dioxide difference as an indicator of cardiac index.
MedLine Citation:
PMID:  15803301     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The mixed venous-arterial (v-a) pCO(2) difference has been shown to be inversely correlated with the cardiac index (CI). A central venous pCO(2), which is easier to obtain, may provide similar information. The purpose of this study was to examine the correlation between the central venous-arterial pCO(2) difference and CI. DESIGN: Prospective, cohort study. SETTING: Intensive care unit of an urban tertiary care hospital. PATIENTS AND PARTICIPANTS: Eighty-three consecutive intensive care unit patients. MEASUREMENTS: Simultaneous blood gases from the arterial, pulmonary artery (PA), and central venous (CV) catheters were obtained. At the same time point, cardiac indices were measured by the thermodilution technique (an average of three measurements). The cardiac indices obtained by the venous-arterial differences were compared with those determined by thermodilution. RESULTS: The correlation (R(2)) between the mixed venous-arterial pCO(2) difference and cardiac index was 0.903 (p <0.0001), and the correlation between the central venous-arterial pCO(2) difference and cardiac index was 0.892 (p <0.0001). The regression equations for these relationships were natural log (CI)=1.837-0.159 (v-a) CO(2) for the PA and natural log (CI)=1.787-0.151 (v-a) CO(2) for the CV (p <0.0001 for both). The root-mean-squared error for the PA and CV regression equations were 0.095 and 0.101, respectively. CONCLUSION: Venous-arterial pCO(2) differences obtained from both the PA and CV circulations inversely correlate with the cardiac index. Substitution of a central for a mixed venous-arterial pCO(2) difference provides an accurate alternative method for calculation of cardiac output.
Joseph Cuschieri; Emanuel P Rivers; Michael W Donnino; Marius Katilius; Gordon Jacobsen; H Bryant Nguyen; Nikolai Pamukov; H Mathilda Horst
Publication Detail:
Type:  Comparative Study; Evaluation Studies; Journal Article     Date:  2005-04-01
Journal Detail:
Title:  Intensive care medicine     Volume:  31     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  2005 Jun 
Date Detail:
Created Date:  2005-06-03     Completed Date:  2006-01-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  818-22     Citation Subset:  IM    
Department of Surgery, Henry Ford Health Systems, Detroit, MI, USA.
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MeSH Terms
Aged, 80 and over
Blood Gas Analysis / methods*
Carbon Dioxide / blood
Cardiac Output*
Catheterization, Central Venous*
Catheterization, Swan-Ganz
Linear Models
Middle Aged
Partial Pressure
Prospective Studies
Reg. No./Substance:
124-38-9/Carbon Dioxide
Comment In:
Intensive Care Med. 2005 Aug;31(8):1141   [PMID:  15997370 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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