| Central vasopressin V1-receptors mediate indomethacin-induced antipyresis in rats. | |
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MedLine Citation:
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PMID: 2785772 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Central microinjection or infusion of an arginine vasopressin (AVP) V1-receptor antagonist within the brain of the conscious, unrestrained, and febrile rat inhibited or abolished the antipyretic effects of peripherally administered indomethacin (Indo). The degree of Indo-induced antipyresis was determined by 2-h thermal indexes (degree C.h) calculated from the time of Indo injection. Microinjection of saline or V1-receptor antagonist within the ventral septal area (VSA) of the rat brain immediately followed by intraperitoneal Indo evoked antipyretic responses of -1.63 +/- 0.17 and -0.24 +/- 0.09 degrees C.h, respectively (P less than 0.01). Infusion of the VSA with saline or V1-receptor antagonist before and after Indo resulted in thermal indexes of -1.35 +/- 0.16 and 0.13 +/- 0.30 degree C.h, respectively (P less than 0.01). Central microinjection of a V2-receptor antagonist did not significantly effect Indo-induced antipyresis compared with paired saline controls. Neither saline nor the V1-receptor antagonist affected nonfebrile body temperature when microinjected into the VSA. These data indicate the importance of AVP V1-receptors within the VSA in mediating the potent fever-reducing properties of the antipyretic drug Indo. Furthermore, these data call into question whether prostaglandin synthesis inhibition is a sufficient explanation of drug-induced antipyresis. |
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Authors:
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M F Wilkinson; N W Kasting |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of physiology Volume: 256 ISSN: 0002-9513 ISO Abbreviation: Am. J. Physiol. Publication Date: 1989 May |
Date Detail:
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Created Date: 1989-06-16 Completed Date: 1989-06-16 Revised Date: 2008-08-16 |
Medline Journal Info:
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Nlm Unique ID: 0370511 Medline TA: Am J Physiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: R1164-8 Citation Subset: IM |
Affiliation:
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Department of Physiology, Faculty of Medicine, University of British Columbia, Vancouver, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Inflammatory Agents, Non-Steroidal / pharmacology* Arginine Vasopressin / analogs & derivatives, pharmacology Body Temperature / drug effects Brain / metabolism* Fever / physiopathology Indomethacin / pharmacology* Injections Male Rats Rats, Inbred Strains Receptors, Angiotensin / metabolism, physiology* Receptors, Vasopressin* Septum Pellucidum Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Anti-Inflammatory Agents, Non-Steroidal; 0/Receptors, Angiotensin; 0/Receptors, Vasopressin; 113-79-1/Arginine Vasopressin; 53-86-1/Indomethacin; 73168-24-8/vasopressin, 1-(1-mercaptocyclohexaneacetic acid)-2-(O- methyl-L-tyrosine)-8-L-arginine- |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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