| Central trigeminal involvement in multiple sclerosis using high-resolution MRI at 3 T. | |
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MedLine Citation:
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PMID: 20505029 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Trigeminal neuralgia and sensory disturbance is common in multiple sclerosis (MS). Recent literature suggests that signal abnormalities in the cisternal trigeminal nerve and pontine root entry zone are seen in approximately 3% of MS patients, using conventional diagnostic MRI. The objective of this study was to determine the prevalence of trigeminal lesions using high-resolution MRI at 3T. Forty-seven patients with clinically definite MS, chosen at random from the outpatient population of a neuroscience centre underwent MRI on a Siemens 3T Trio machine. Three 3D sequences of T2 TSE (turbo spin echo), T2 FLAIR (fluid attenuated inversion recovery) and T1 IR (inversion recovery) were acquired in the coronal plane. The sequences were of contiguous 1 mm slices with in-plane resolution of up to 0.5 mm by 0.5 mm. Images were read by both a neurologist and a neuroradiologist. Any clinical history of trigeminal symptoms was determined for all subjects. The results showed that 11 patients (23%) had high signal in the trigeminal root entry zone and either the trans-cisternal nerve or pontine nucleus; example images are given. MRI changes did not correspond to clinical symptoms (chi square probability 1.000). The study concludes that high-resolution MRI at 3T yielded a high prevalence of detectable trigeminal abnormality in the MS sample studied. MRI involvement did not correspond to trigeminal symptoms. |
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Authors:
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R J Mills; C A Young; E T Smith |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The British journal of radiology Volume: 83 ISSN: 1748-880X ISO Abbreviation: Br J Radiol Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-27 Completed Date: 2010-08-02 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0373125 Medline TA: Br J Radiol Country: England |
Other Details:
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Languages: eng Pagination: 493-8 Citation Subset: AIM; IM |
Affiliation:
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The Walton Centre for Neurology and Neurosurgery, Departments of Neurology, Liverpool L9 7LJ, UK. rjm@crazydiamond.co.uk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Female Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods Imaging, Three-Dimensional / methods Magnetic Resonance Imaging / methods Male Middle Aged Multiple Sclerosis / complications Prospective Studies Trigeminal Nerve / pathology* Trigeminal Nerve Diseases / complications, diagnosis* Trigeminal Neuralgia / complications, diagnosis |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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