| Central systolic augmentation indexes and urinary sodium in a white population. | |
| | |
MedLine Citation:
|
PMID: 23382332 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
BACKGROUND The association between cardiovascular health and salt intake remains controversial. The objective of our study was to assess the association between arterial stiffness and urinary sodium, both cross-sectionally and prospectively. METHODS In 630 participants (mean age 40.6 years; 51% women), randomly recruited from a Flemish population, we measured sodium and creatinine in 24-hour urine samples at baseline and follow-up (median, 9.7 years) and the carotid and aortic augmentation indexes (AIs) standardized to heart rate at follow-up only. RESULTS From baseline to follow-up, the urinary sodium concentration decreased (117.1 vs. 105.2 mmol/L; P < 0.0001), whereas 24-hour urinary sodium did not change significantly (166.5 vs. 171.5 mmol/L; P = 0.12). In multivariable-adjusted longitudinal analyses, a 40 mmol/L (~1 SD) increase in the urinary sodium concentration was independently and inversely associated with the carotid AI (effect size, -1.38±0.66%; P = 0.04) and aortic AI (-1.54±0.72%; P = 0.02). In cross-sectional analyses of follow-up data, these estimates were -1.26±0.70% (P = 0.07) and -1.52±0.76% (P = 0.04), respectively. In the longitudinal and cross-sectional analyses, the carotid and aortic AIs were unrelated to the 24-hour urinary excretion of sodium. CONCLUSIONS Our study showed an inverse association between the central arterial AIs and the urinary sodium concentration. Further research is required to consolidate our findings, to unravel the underlying mechanism, and to establish the role of renal vasodilatation in the maintenance of sodium balance. |
| | |
Authors:
|
Yan-Ping Liu; Lutgarde Thijs; Tatiana Kuznetsova; Yu-Mei Gu; Kei Asayama; Katarzyna Stolarz-Skrzypek; Yu Jin; Peter Verhamme; Harry A J Struijker-Boudier; Jan A Staessen |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: American journal of hypertension Volume: 26 ISSN: 1941-7225 ISO Abbreviation: Am. J. Hypertens. Publication Date: 2013 Jan |
Date Detail:
|
Created Date: 2013-02-05 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8803676 Medline TA: Am J Hypertens Country: United States |
Other Details:
|
Languages: eng Pagination: 95-103 Citation Subset: IM |
Affiliation:
|
Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium; |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Normotension, prehypertension, and hypertension in urban middle-class subjects in India: prevalence,...
Next Document: Reproductive dysfunction in female rats with renovascular hypertension.