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Central systolic augmentation indexes and urinary sodium in a white population.
MedLine Citation:
PMID:  23382332     Owner:  NLM     Status:  In-Data-Review    
BACKGROUND The association between cardiovascular health and salt intake remains controversial. The objective of our study was to assess the association between arterial stiffness and urinary sodium, both cross-sectionally and prospectively. METHODS In 630 participants (mean age 40.6 years; 51% women), randomly recruited from a Flemish population, we measured sodium and creatinine in 24-hour urine samples at baseline and follow-up (median, 9.7 years) and the carotid and aortic augmentation indexes (AIs) standardized to heart rate at follow-up only. RESULTS From baseline to follow-up, the urinary sodium concentration decreased (117.1 vs. 105.2 mmol/L; P < 0.0001), whereas 24-hour urinary sodium did not change significantly (166.5 vs. 171.5 mmol/L; P = 0.12). In multivariable-adjusted longitudinal analyses, a 40 mmol/L (~1 SD) increase in the urinary sodium concentration was independently and inversely associated with the carotid AI (effect size, -1.38±0.66%; P = 0.04) and aortic AI (-1.54±0.72%; P = 0.02). In cross-sectional analyses of follow-up data, these estimates were -1.26±0.70% (P = 0.07) and -1.52±0.76% (P = 0.04), respectively. In the longitudinal and cross-sectional analyses, the carotid and aortic AIs were unrelated to the 24-hour urinary excretion of sodium. CONCLUSIONS Our study showed an inverse association between the central arterial AIs and the urinary sodium concentration. Further research is required to consolidate our findings, to unravel the underlying mechanism, and to establish the role of renal vasodilatation in the maintenance of sodium balance.
Yan-Ping Liu; Lutgarde Thijs; Tatiana Kuznetsova; Yu-Mei Gu; Kei Asayama; Katarzyna Stolarz-Skrzypek; Yu Jin; Peter Verhamme; Harry A J Struijker-Boudier; Jan A Staessen
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  26     ISSN:  1941-7225     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-02-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  95-103     Citation Subset:  IM    
Studies Coordinating Centre, Division of Hypertension and Cardiovascular Rehabilitation, Department of Cardiovascular Sciences, University of Leuven, Leuven, Belgium;
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