Document Detail

Central sympathetic outflow to skeletal muscle: the major link between non-esterified fatty acids and elevated blood pressure?
MedLine Citation:
PMID:  19594440     Owner:  NLM     Status:  MEDLINE    
Sympathetic nervous system activation is a hallmark of several conditions associated with an adverse prognosis, including hypertension and the metabolic syndrome. Proposed mediators of increased sympathetic drive include hyperinsulinaemia, leptin, NEFAs (non-esterified fatty acids), pro-inflammatory cytokines, baroreflex impairment and others. The role of NEFAs appears to be of particular importance given the increased levels observed in human obesity and the experimental results linking the NEFA-induced pressor response to sympathetic activation. Findings from human studies have yielded conflicting results with regards to a sympathetically mediated association between NEFAs and elevated arterial blood pressure. In the present issue of Clinical Science, Florian and Pawelczyk present some interesting results obtained from a small number of healthy normotensive lean volunteers who were exposed to NEFA infusion and cardiovascular and sympathetic monitoring using state of the art methodology that appears to be in support of such a link. However, several methodological and conceptual considerations need to be taken into account when interpreting the results from this study. Put into perspective, the case for a substantial sympathetically mediated pressor response to NEFA infusion does not appear to be a very strong one.
Markus Schlaich
Publication Detail:
Type:  Comment; Journal Article     Date:  2009-10-02
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  118     ISSN:  1470-8736     ISO Abbreviation:  Clin. Sci.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2009-09-28     Completed Date:  2009-12-02     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-5     Citation Subset:  IM    
Neurovascular Hypertension and Kidney Disease Laboratory, Alfred and Baker Hypertension Network, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 8008, Australia.
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MeSH Terms
Blood Pressure / drug effects,  physiology
Fatty Acids, Nonesterified / pharmacology*
Hypertension / physiopathology*
Muscle, Skeletal / innervation*
Sympathetic Nervous System / drug effects,  physiopathology*
Reg. No./Substance:
0/Fatty Acids, Nonesterified
Comment On:
Clin Sci (Lond). 2010 Jan;118(1):61-9   [PMID:  19426144 ]

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