Document Detail


Central sleep apnea: implications for congestive heart failure.
MedLine Citation:
PMID:  18574295     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Congestive heart failure (HF), an exceedingly common and costly disease, is frequently seen in association with central sleep apnea (CSA), which often manifests as a periodic breathing rhythm referred to as Cheyne-Stokes respiration. CSA has historically been considered to be a marker of heart disease, since improvement in cardiac status is often associated with the attenuation of CSA. However, this mirroring of HF and CSA may suggest bidirectional importance to their relationship. In fact, observational data suggest that CSA, associated with repetitive oxyhemoglobin desaturations and surges in sympathetic neural activity, may be of pathophysiologic significance in HF outcomes. In light of the disappointing results from the first large trial assessing therapy with continuous positive airway pressure in patients with CSA and HF, further large-scale interventional trials will be needed to assess the role, if any, of CSA treatment on the outcomes of patients with HF. This review will discuss epidemiologic, pathophysiologic, diagnostic, and therapeutic considerations of CSA in the setting of HF.
Authors:
Arturo Garcia-Touchard; Virend K Somers; Lyle J Olson; Sean M Caples
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Chest     Volume:  133     ISSN:  0012-3692     ISO Abbreviation:  Chest     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-24     Completed Date:  2008-07-31     Revised Date:  2014-09-18    
Medline Journal Info:
Nlm Unique ID:  0231335     Medline TA:  Chest     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1495-504     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Carbon Dioxide / pharmacology*,  therapeutic use
Continuous Positive Airway Pressure*
Female
Heart Failure* / etiology,  mortality,  physiopathology
Humans
Male
Oxygen / therapeutic use
Randomized Controlled Trials as Topic
Respiration / drug effects
Sleep Apnea, Central* / complications,  diagnosis,  physiopathology
Grant Support
ID/Acronym/Agency:
HL 65176/HL/NHLBI NIH HHS; HL 63747/HL/NHLBI NIH HHS; HL 70302/HL/NHLBI NIH HHS; HL 71478/HL/NHLBI NIH HHS; HL 73211/HL/NHLBI NIH HHS; M01 RR 00585/RR/NCRR NIH HHS; R01 HL071478/HL/NHLBI NIH HHS; R01 HL071478-05/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
142M471B3J/Carbon Dioxide; S88TT14065/Oxygen
Comments/Corrections

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