Document Detail

Central site for pressor action of blood-borne angiotensin in rat.
MedLine Citation:
PMID:  7435606     Owner:  NLM     Status:  MEDLINE    
A previous study demonstrated that the threshold dose of intra-arterial angiotensin II required to induce a pressor response in the rat was significantly lower when the drug was administered into the carotid artery than when administered into the abdominal aorta. This result was interpreted to indicate that part of the increase in arterial pressure produced by low concentrations of blood-borne angiotensin in this species was the result of an effect on structures in the central nervous system selectively accessible via the carotid vascular bed. The purpose of the present study was to establish more precisely the site of the pressor action of angiotensin within the central nervous system. The central component of the pressor effect of angiotensin was quantified as the difference in pressor responses to intracarotid and intra-aortic infusions of angiotensin II (delta c-a). In conscious rats, delta c-a was attenuated by administration of the angiotensin antagonist, saralasin, into the third cerebral ventricle. In rats with chronic electrolytic lesions of the anteroventral third ventricle (AV3V), delta c-a was abolished. Periventricular structures surrounding the third ventricle appear to mediate the central component of the pressor action of blood-borne angiotensin in the rat.
G D Fink; J R Haywood; W J Bryan; W Packwood; M J Brody
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of physiology     Volume:  239     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1980 Sep 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  R358-61     Citation Subset:  IM    
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MeSH Terms
Angiotensin II / administration & dosage,  pharmacology*
Blood Pressure / drug effects*
Brain Mapping
Carotid Arteries
Cerebral Ventricles / physiology*
Injections, Intra-Arterial
Rats / physiology*
Saralasin / pharmacology
Reg. No./Substance:
11128-99-7/Angiotensin II; 34273-10-4/Saralasin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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