Document Detail

Central serous chorioretinopathy associated with sildenafil.
MedLine Citation:
PMID:  18398363     Owner:  NLM     Status:  MEDLINE    
PURPOSE:: To investigate a suspected relationship between central serous chorioretinopathy (CSC) and sildenafil therapy. METHODS:: For this retrospective, observational case series, the authors reviewed over 1,500 case reports of sildenafil-associated ocular side effects from the postmarketing surveillance databases of the Food and Drug Administration (FDA), the World Health Organization (WHO), and the National Registry of Drug-Induced Ocular Side Effects. They also performed a Medline literature search for "retinopathy, retinal edema, macular edema" (terms associated with CSC) and "sildenafil." They identified 11 cases of CSC in men taking sildenafil. RESULTS:: In 8 of 11 cases, patients stopped sildenafil therapy when CSC occurred. In 6 of these 8 cases, patients' vision improved after sildenafil cessation. In 3 cases, effects recurred when patients resumed sildenafil therapy, but stopping therapy was not associated with improvement of CSC in every case. Two patients continued to experience CSC after sildenafil cessation. CONCLUSION:: Practitioners who see patients with refractory CSC should consider recommending cessation of sildenafil therapy; however, because of the cyclic nature of CSC, a causal relationship has not yet been established. Additional possible case reports can be sent to the National Registry of Drug-Induced Ocular Side Effects, the FDA, the WHO, or the manufacturer.
Frederick W Fraunfelder; Frederick T Fraunfelder
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Retina (Philadelphia, Pa.)     Volume:  28     ISSN:  0275-004X     ISO Abbreviation:  Retina (Philadelphia, Pa.)     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-04-09     Completed Date:  2008-05-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8309919     Medline TA:  Retina     Country:  United States    
Other Details:
Languages:  eng     Pagination:  606-9     Citation Subset:  IM    
Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239-4197, USA.
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MeSH Terms
3',5'-Cyclic-GMP Phosphodiesterases / antagonists & inhibitors
Choroid Diseases / chemically induced*
Databases, Factual
Middle Aged
Phosphodiesterase Inhibitors / adverse effects*
Piperazines / adverse effects*
Product Surveillance, Postmarketing
Purines / adverse effects
Retinal Diseases / chemically induced*
Retrospective Studies
Sulfones / adverse effects*
Reg. No./Substance:
0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 139755-83-2/sildenafil; EC',5'-Cyclic-GMP Phosphodiesterases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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