| Central serous chorioretinopathy associated with sildenafil. | |
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MedLine Citation:
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PMID: 18398363 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE:: To investigate a suspected relationship between central serous chorioretinopathy (CSC) and sildenafil therapy. METHODS:: For this retrospective, observational case series, the authors reviewed over 1,500 case reports of sildenafil-associated ocular side effects from the postmarketing surveillance databases of the Food and Drug Administration (FDA), the World Health Organization (WHO), and the National Registry of Drug-Induced Ocular Side Effects. They also performed a Medline literature search for "retinopathy, retinal edema, macular edema" (terms associated with CSC) and "sildenafil." They identified 11 cases of CSC in men taking sildenafil. RESULTS:: In 8 of 11 cases, patients stopped sildenafil therapy when CSC occurred. In 6 of these 8 cases, patients' vision improved after sildenafil cessation. In 3 cases, effects recurred when patients resumed sildenafil therapy, but stopping therapy was not associated with improvement of CSC in every case. Two patients continued to experience CSC after sildenafil cessation. CONCLUSION:: Practitioners who see patients with refractory CSC should consider recommending cessation of sildenafil therapy; however, because of the cyclic nature of CSC, a causal relationship has not yet been established. Additional possible case reports can be sent to the National Registry of Drug-Induced Ocular Side Effects, the FDA, the WHO, or the manufacturer. |
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Authors:
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Frederick W Fraunfelder; Frederick T Fraunfelder |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Retina (Philadelphia, Pa.) Volume: 28 ISSN: 0275-004X ISO Abbreviation: Retina (Philadelphia, Pa.) Publication Date: 2008 Apr |
Date Detail:
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Created Date: 2008-04-09 Completed Date: 2008-05-20 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8309919 Medline TA: Retina Country: United States |
Other Details:
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Languages: eng Pagination: 606-9 Citation Subset: IM |
Affiliation:
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Casey Eye Institute, Oregon Health & Science University, Portland, OR 97239-4197, USA. eyedrug@ohsu.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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3',5'-Cyclic-GMP Phosphodiesterases
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antagonists & inhibitors Adult Aged Choroid Diseases / chemically induced* Databases, Factual Humans Male Middle Aged Phosphodiesterase Inhibitors / adverse effects* Piperazines / adverse effects* Product Surveillance, Postmarketing Purines / adverse effects Retinal Diseases / chemically induced* Retrospective Studies Serum Sulfones / adverse effects* |
| Chemical | |
Reg. No./Substance:
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0/Phosphodiesterase Inhibitors; 0/Piperazines; 0/Purines; 0/Sulfones; 139755-83-2/sildenafil; EC 3.1.4.35/3',5'-Cyclic-GMP Phosphodiesterases |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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