Document Detail


Central retinal vein occlusion in a sickle cell trait carrier after a cycling race.
MedLine Citation:
PMID:  19092708     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 26-yr-old man with sickle cell trait (SCT) suddenly lost visual acuity in the left eye after a cycling race in hot tropical environment. The cause was massive central retinal vein occlusion (CRVO) with hemorrhaging that rapidly worsened to neovascular glaucoma. Although medically treated, the eye is now marked by total retinal detachment. Cardiovascular function assessment shows no electrocardiographic abnormalities, no anomaly in the supra-aortic tree, and no evidence of structural heart disease. Although normal coagulation markers values (i.e., activated partial thromboplastin time, prothrombin time, fibrinogen concentration, antithrombin III, factor V, proteins C and S) were observed 2.5 months after the clinical event, a transesophageal echocardiogram performed few hours after the incident revealed the presence of four thrombi in the left atrium suggesting a postexercise hypercoagulable state at that time. Hemorheological measurements at distance of the events demonstrated high red blood cell rigidity at baseline. Therefore, marked blood rheological impairment and activation of the coagulation pathway in response to the heavy and prolonged cycling race could have promoted CRVO in this cyclist carrying SCT. These data suggest that SCT could be considered as a risk factor for significant ocular complications when severe exercise is performed and support the idea that SCT is a contributing factor in blood rheology and vascular dysfunctions.
Authors:
Mona Hedreville; Philippe Connes; Marc Romana; Guillaume Magnaval; Thierry David; Marie-Dominique Hardy-Dessources; Marie-Sylvaine Belloy; Maryse Etienne-Julan; Olivier Hue
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  41     ISSN:  1530-0315     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-24     Completed Date:  2009-05-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14-8     Citation Subset:  IM; S    
Affiliation:
Laboratory ACTES UPRES-EA 3596, Department of Physiology, University of the French West Indies, Campus of Fouillole, Pointe-a-Pitre, Guadeloupe, France.
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MeSH Terms
Descriptor/Qualifier:
Acclimatization
Adult
Bicycling / physiology*
Heat Stress Disorders / complications*
Humans
Male
Retinal Vein / pathology*
Retinal Vein Occlusion / etiology,  physiopathology*,  therapy
Sickle Cell Trait / physiopathology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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