Document Detail

Central and regional normetadrenaline in evaluation of neurogenic aspects of hypertension: aid to diagnosis of phaeochromocytoma.
MedLine Citation:
PMID:  7449270     Owner:  NLM     Status:  MEDLINE    
1. Free normetadrenaline concentrations in plasma of patients with phaeochromocytoma were elevated 20-1000-fold as compared with values in primary hypertensive subjects. 2. Spinal fluid normetadrenaline was 1.8-16% of the simultaneous plasma values in patients with phaeochromocytoma, whereas levels in spinal fluid exceeded those of plasma in primary hypertension. 3. Spinal fluid noradrenaline was 7.9-58% of simultaneous values of plasma noradrenaline in patients with phaeochromocytoma, whereas values in plasma and cerebrospinal fluid were similar in primary hypertension. 4. Plasma noradrenaline and normetadrenaline levels were both elevated in veins from regions subsequently found to harbour chromaffin tumours. 5. The excessive amounts of normetadrenaline produced in phaeochromocytoma enters plasma but not spinal fluid and can be used for diagnosis and localization of phaeochromocytoma.
V DeQuattro; P Sullivan; A Foti; J Bornheimer; S Schoentgen; G Versales; D Levine; K Kobayashi
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Clinical science (London, England : 1979)     Volume:  59 Suppl 6     ISSN:  0143-5221     ISO Abbreviation:  Clin. Sci.     Publication Date:  1980 Dec 
Date Detail:
Created Date:  1981-03-27     Completed Date:  1981-03-27     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7905731     Medline TA:  Clin Sci (Lond)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  275s-277s     Citation Subset:  IM    
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MeSH Terms
Adrenal Gland Neoplasms / blood*,  cerebrospinal fluid,  diagnosis
Epinephrine / blood
Hypertension / blood*
Middle Aged
Norepinephrine / blood
Normetanephrine / blood*,  cerebrospinal fluid
Pheochromocytoma / blood*,  cerebrospinal fluid,  diagnosis
Grant Support
Reg. No./Substance:
51-41-2/Norepinephrine; 51-43-4/Epinephrine; 97-31-4/Normetanephrine

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