Document Detail

Central and regional hemodynamics in prolonged space flights.
MedLine Citation:
PMID:  11542423     Owner:  NASA     Status:  MEDLINE    
This paper presents the results of measuring central and regional (head, forearm, calf) hemodynamics at rest and during provocative tests by the method of tetrapolar rheography in the course of Salyut-6-Soyuz and Salyut-7-Soyuz missions. The measurements were carried out during short-term (19 man-flights of 7 days in duration) and long-term (21 man-flights of 65-237 days in duration) manned missions. At rest, stroke volume (SV) and cardiac output (CO) as well as heart rate (HR) decreased insignificantly (in short-term flights) or remained essentially unchanged (in long-term flights). In prolonged flights CO increased significantly in response to exercise tests due to an increase in HR and the lack of changes in SV. After exercise tests SV and CO decreased as compared to the preflight level. During lower body negative pressure (LBNP) tests HR and CO were slightly higher than preflight. Changes in regional hemodynamics included a distinct decrease of pulse blood filling (PBF) of the calf, a reduction of the tone of large vessels of the calf and small vessels of the forearm. Head examination (in the region of the internal carotid artery) showed a decrease of PBF of the left hemisphere (during flight months 2-8) and a distinct decline of the tone of small vessels, mainly, in the right hemisphere. During LBNP tests the tone of pre- and postcapillary vessels of the brain returned to normal while PBF of the right and left hemisphere vessels declined. It has been shown that regional circulation variations depend on the area examined and are induced by a rearrangement of total hemodynamics of the human body in microgravity. This paper reviews the data concerning changes in central and regional circulation of men in space flights of different duration.
O G Gazenko; E B Shulzhenko; V F Turchaninova; A D Egorov
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Acta astronautica     Volume:  17     ISSN:  0094-5765     ISO Abbreviation:  Acta Astronaut     Publication Date:  1988 Feb 
Date Detail:
Created Date:  1999-12-06     Completed Date:  1999-12-06     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9890631     Medline TA:  Acta Astronaut     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  173-9     Citation Subset:  S    
Institute of Biomedical Problems, Moscow, USSR.
Space Flight Mission:
Flight Experiment; Salyut 6 Project; Salyut 7 Project; Soyuz Project; long duration; manned; short duration
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MeSH Terms
Adaptation, Physiological
Arm / blood supply
Cardiac Output / physiology
Carotid Artery, Internal
Cerebrovascular Circulation / physiology
Heart Rate / physiology
Hemodynamics / physiology*
Leg / blood supply
Lower Body Negative Pressure
Plethysmography, Impedance / methods
Regional Blood Flow
Space Flight*
Stroke Volume / physiology
Weightlessness Countermeasures

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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