Document Detail


Central prostaglandins in food intake regulation.
MedLine Citation:
PMID:  18662860     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Prostaglandin (PG) E(2) and PGD(2), produced in the mammalian central nervous system, are known to have a variety of central actions on sleep, body temperature, and pain response via G-protein-coupled seven-transmembrane receptors. We found that centrally administered PGE(2) suppressed food intake via the EP(4) receptor, whereas PGD(2) increased food intake via the DP(1) receptor coupled to the neuropeptide Y Y(1) receptor. In this review, we summarize roles of central PGs in food intake regulation and discuss the relation between PGs and neuropeptides controlling food intake.
Authors:
Kousaku Ohinata; Masaaki Yoshikawa
Publication Detail:
Type:  Journal Article; Review     Date:  2008-07-26
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  24     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-26     Completed Date:  2009-01-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  798-801     Citation Subset:  IM    
Affiliation:
Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, Kyoto, Japan. ohinata@kais.kyoto-u.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Animals
Appetite Regulation / physiology
Eating / physiology*
Feeding Behavior / physiology*
Humans
Hypothalamus / metabolism
Mice
Neuropeptides / metabolism,  pharmacology
Prostaglandins / chemistry,  metabolism*,  pharmacology*
Chemical
Reg. No./Substance:
0/Neuropeptides; 0/Prostaglandins

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