| Central processing of rectal pain in patients with irritable bowel syndrome: an fMRI study. | |
| | |
MedLine Citation:
|
PMID: 11926209 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: In healthy subjects, the neural correlates of visceral pain bear much similarity with the correlates of somatic pain. In patients with irritable bowel syndrome, the central nervous system is believed to play a strong modulatory or etiological role in the pathophysiology of the disease. We hypothesize that this role must be reflected in aberrations of central functional responses to noxious visceral stimulation in these patients. To verify this hypothesis, we have induced transient rectal pain in patients and assessed the functional responses of the brain by means of functional magnetic resonance imaging. METHODS: Twelve right-handed patients (11 female) were examined. Functional imaging (1.5 T) was performed following a block paradigm, alternating epochs with and without noxious stimulation of the rectum. Rectal pain was induced by inflating a latex balloon. Whole-brain coverage was achieved by means of echo-planar magnetic resonance acquisition. RESULTS: A strong variability of the individual responses to rectal pain was found in patients with irritable bowel syndrome. Significant activations were found in only two patients, and group analysis did not reveal significant activations. In contrast, all patients exhibited significant deactivations. Group analysis revealed significant deactivations within the right insula, the right amygdala, and the right striatum. CONCLUSIONS: This study reveals aberrant functional responses to noxious rectal stimulation in patients with irritable bowel syndrome. Those results add grounds to the hypothesis that the central nervous system plays a significant role in the pathophysiology of this syndrome. |
| | |
Authors:
|
B Bonaz; M Baciu; E Papillon; R Bost; N Gueddah; J F Le Bas; J Fournet; C Segebarth |
Related Documents
:
|
21993989 - Feline pediatrics: how to treat the small and the sick. 8063029 - Female fertility, obstetric and gynaecological history in coeliac disease. a case contr... 17434349 - Factors associated with the technical performance of colonoscopy: an epage study. 8803859 - Relationship between the use of unconventional therapies and disease-related concerns: ... 20848469 - Probiotic and prebiotic use in patients with inflammatory bowel disease: a case-control... 15125469 - Health-related quality of life in patients with inflammatory bowel disease five years a... 15105029 - Comparison of two nutrition assessment techniques in hospitalized patients. 8743229 - Physicians' attitudes and beliefs about deaf patients. 15857489 - Laboratory safety monitoring of chronic medications in ambulatory care settings. |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of gastroenterology Volume: 97 ISSN: 0002-9270 ISO Abbreviation: Am. J. Gastroenterol. Publication Date: 2002 Mar |
Date Detail:
|
Created Date: 2002-03-29 Completed Date: 2002-04-19 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0421030 Medline TA: Am J Gastroenterol Country: United States |
Other Details:
|
Languages: eng Pagination: 654-61 Citation Subset: IM |
Affiliation:
|
Département d'Hépato-Gastroentérologie, CHU, Grenoble, France. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Aged Central Nervous System / pathology*, physiopathology* Colonic Diseases, Functional / complications, pathology*, physiopathology* Female Humans Magnetic Resonance Imaging* Male Middle Aged Neural Conduction / physiology Pain / etiology, pathology*, physiopathology* Pain Threshold / physiology Rectal Diseases / etiology, pathology*, physiopathology* Rectum / pathology, physiopathology Sensory Thresholds |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Outcomes of infants born to mothers with inflammatory bowel disease: a population-based cohort study...
Next Document: High prevalence of undetected ulcerative colitis: data from the Nottingham fecal occult blood screen...