| Central players in inherited lipodystrophies. | |
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MedLine Citation:
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PMID: 20621503 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Common obesity and inherited lipodystrophies, rare disorders characterized by a partial (familial partial lipodystrophy; FPLD) or complete (congenital generalized lipodystrophy; CGL) lack of adipose tissue, are both associated with metabolic complications such as insulin resistance and type 2 diabetes. Mutations in the transcription factor peroxisome proliferator activated receptor (PPAR)γ and a number of its downstream target genes result in lipodystrophy. We hypothesize that signalling by another transcription factor, sterol response element binding protein (SREBP)1c, also needs to be intact to prevent lipodystrophy. The future challenge is to understand how inactivation of such central players or of their upstream regulators or downstream effectors can affect adipose tissue in a depot-specific fashion. |
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Authors:
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Ellen H Jeninga; Eric Kalkhoven |
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Publication Detail:
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Type: Journal Article Date: 2010-07-10 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 21 ISSN: 1879-3061 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2010 Oct |
Date Detail:
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Created Date: 2010-10-04 Completed Date: 2011-01-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 581-8 Citation Subset: IM |
Copyright Information:
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Copyright © 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Department of Metabolic and Endocrine Diseases, UMC Utrecht, Lundlaan 6, 3584 EA Utrecht, The Netherlands. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adipose Tissue
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metabolism,
pathology Animals Humans Lipodystrophy / genetics, metabolism* Models, Biological PPAR gamma / genetics, metabolism Signal Transduction / genetics, physiology Sterol Regulatory Element Binding Protein 1 / genetics, metabolism |
| Chemical | |
Reg. No./Substance:
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0/PPAR gamma; 0/Sterol Regulatory Element Binding Protein 1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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