Document Detail

Central and peripheral neural responses in males with idiopathic hypogonadotropic hypogonadism.
MedLine Citation:
PMID:  8884539     Owner:  NLM     Status:  MEDLINE    
It has previously been shown that abnormal neurophysiologic responses are associated with Kallmann's syndrome. However, little is known about neurophysiologic responses in idiopathic hypogonadotropic hypogonadism (IHH). Fifty-six untreated male patients with IHH (mean age: 20 +/- 0.7 years) were compared with a control group of 20 age-matched male subjects to determine whether IHH can lead to alterations in somatosensory evoked potentials (SSEPs) and brainstem auditory evoked potentials (BAEPs). We have also investigated the effect of gonadotropin replacement (hCG/hMG) therapy on these tests in 20 randomly selected patients. Significant cervical 7 (N13), Erb (N9) and thoracic 12 (N22) latency prolongation was observed in median and tibial nerve SSEPs in patients with IHH as compared with a matched control group. Other components of SSEPs and interpeak latencies of BAEPs yielded no significant difference between untreated patients and control group. Abnormal components of SSEPs did not correlate with basal hormone levels and did not improve with gonadotropin therapy. We conclude that IHH results abnormalities in peripheral but not central nervous system components of SSEPs and that short term gonadotropin treatment cannot correct these abnormalities.
M Ozata; A Ozkardes; M Bulur; Z Beyhan; A Corakçi; M Yardim; M A Gundogan
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Journal of endocrinological investigation     Volume:  19     ISSN:  0391-4097     ISO Abbreviation:  J. Endocrinol. Invest.     Publication Date:    1996 Jul-Aug
Date Detail:
Created Date:  1997-02-06     Completed Date:  1997-02-06     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7806594     Medline TA:  J Endocrinol Invest     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  449-54     Citation Subset:  IM    
Department of Endocrinology and Metabolism, Gulhane School of Medicine, Etlik-Ankara, Turkey.
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MeSH Terms
Central Nervous System / drug effects,  physiology*
Chorionic Gonadotropin / pharmacology*,  therapeutic use
Evoked Potentials, Auditory, Brain Stem / drug effects,  physiology*
Evoked Potentials, Somatosensory / drug effects,  physiology*
Hypogonadism / drug therapy*,  physiopathology
Peripheral Nervous System / drug effects,  physiology*
Reference Values
Reg. No./Substance:
0/Chorionic Gonadotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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