Document Detail


Central and peripheral haemodynamic responses to felodipine in congestive heart failure.
MedLine Citation:
PMID:  1743253     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Using non-invasive radionuclide techniques, we studied the arterial and venous effects of 0.1 mg/kg oral felodipine in 12 men with heart failure due to ischaemic heart disease aged 37-72 y. All were in New York Heart Association Class II or III, required frusemide 40-120 mg daily and were clinically stable. Felodipine produced significant falls in blood pressure (-19%) and systemic vascular resistance (-39%) with increases in cardiac index (+34%), heart rate (+12%) and left ventricular ejection fraction (from 0.25 to 0.32). Peripheral venous volume fell by 10.6% after felodipine indicating venoconstriction rather than venodilatation and may be caused by an acute sympathetic reflex associated with the increase in heart rate. Our results confirm that felodipine is an arterial vasodilator. The previously observed changes in cardiac filling pressures may simply represent improved ventricular function as a consequence of reduced afterload, not venodilatation.
Authors:
S Capewell; C G Wathen; A L Muir
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  41     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1991  
Date Detail:
Created Date:  1992-01-15     Completed Date:  1992-01-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  95-8     Citation Subset:  IM    
Affiliation:
Department of Medicine, Royal Infirmary, Edinburgh, UK.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Compliance / drug effects
Felodipine / adverse effects,  therapeutic use*
Heart Failure / drug therapy*,  physiopathology
Hemodynamics / drug effects*
Humans
Male
Middle Aged
Chemical
Reg. No./Substance:
72509-76-3/Felodipine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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