Document Detail


Central and peripheral effects of repeated stress and high NaCl diet on neuropeptide Y.
MedLine Citation:
PMID:  1355917     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study was performed to investigate the influence of repeated psychological stress alone or combined with high NaCl intake on the function of the sympathetic nervous system. In addition, NPY levels have been measured in brain regions of potential importance in the central regulation of stress responses (ventrolateral and dorsomedial medulla, paraventricular and arcuate nucleus of the hypothalamus, and frontal cortex). Normotensive Wistar rats received a standard diet alone or supplemented with NaCl. To accentuate differences in sodium balance, rats on the high NaCl diet (HNa) were uninephrectomized. Half the animals on each diet were subjected to chronic stress using daily sessions (1 h) of immobilization stress. After 12 days, plasma levels of neuropeptide Y (NPY), norepinephrine (NE), and epinephrine (E) were measured basally and in response to acute footshock stress. HNa intake or chronic stress alone did not significantly alter either basal or stimulated plasma levels of NPY. However, combining the treatments produced a significant interaction, increasing the NPY response to footshock by 31% compared to HNa alone (p = 0.039) and by 98% compared to stress alone (p less than 0.001). Chronic stress increased basal levels of NE and enhanced the response to subsequent acute stress: combining the treatments did not yield further increases. Plasma levels of E were not significantly affected by the treatments. In the brain, stress alone had no effect on the NPY levels in the structures studied. HNa intake induced a significant increase in NPY levels of the arcuate nucleus, and produced a significant interaction with stress in the dorsomedial medulla. In a supplementary experiment, to evaluate the role of the autonomic nervous system in plasma NPY responses, treatment with the ganglion blocker hexamethonium was shown to significantly attenuate stress-induced changes in NPY, NE, and E.
Authors:
R Corder; V Castagné; J M Rivet; P Mormède; R C Gaillard
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Physiology & behavior     Volume:  52     ISSN:  0031-9384     ISO Abbreviation:  Physiol. Behav.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-15     Completed Date:  1992-10-15     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0151504     Medline TA:  Physiol Behav     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  205-10     Citation Subset:  IM    
Affiliation:
Unite de Neuroendocrinologie, Hospital Cantonal Universitaire, Geneva, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Animals
Brain Stem / physiology
Catecholamines / metabolism
Central Nervous System / drug effects,  metabolism*
Electroshock
Hexamethonium Compounds / pharmacology
Hypothalamus / physiology
Male
Myocardium / metabolism
Neuropeptide Y / metabolism*
Peripheral Nerves / drug effects,  metabolism*
Prosencephalon / physiology
Rats
Rats, Inbred Strains
Sodium, Dietary / pharmacology*
Stress, Psychological / metabolism*
Tyrosine 3-Monooxygenase / metabolism
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Hexamethonium Compounds; 0/Neuropeptide Y; 0/Sodium, Dietary; EC 1.14.16.2/Tyrosine 3-Monooxygenase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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