Document Detail

Central and peripheral effects of prostaglandin E2 and enprostil on exocrine pancreatic secretion in rats.
MedLine Citation:
PMID:  2502776     Owner:  NLM     Status:  MEDLINE    
Prostaglandin E2 (PGE2) has been reported to exert some centrally mediated effects on intestinal motility and secretion and on gastric secretion, but it is not known whether such central effects exist on pancreatic secretion. The central and peripheral effects of PGE2 and enprostil, a long-acting, potent PGE2 analogue, were studied in conscious and anesthetized rats fitted with pancreatic fistulae. In chronically implanted, conscious rats, PGE2 inhibited the secretion of fluid, bicarbonate, and total protein in the pancreatic juice, both after i.v. or intracerebroventricular (icv) injections. The maximal inhibition was similar after both injection procedures (about 45% for fluid and bicarbonate and 60% for protein), but the potency of PGE2 was three to 10 times greater by the icv than the i.v. route. Enprostil also inhibited pancreatic secretion in a dose-related way. The maximal inhibition was larger than after PGE2 injection (about 70% for fluid and bicarbonate and 90% for protein). The potency of enprostil was five to 10 times lower by the icv than by the i.v. route. The diversion of gastric secretion suppressed the effect of icv PGE2 on fluid and bicarbonate output but not on protein and did not change the effect of enprostil on all the variables of pancreatic secretion. Adrenergic antagonists did not suppress the effect of icv PGE2 or enprostil on pancreatic secretion. In anesthetized rats, i.v. PGE2 inhibited hormone-stimulated protein secretion but did not change fluid and bicarbonate output, while i.v. enprostil inhibited cholecystokinin-stimulated fluid, bicarbonate, and protein output in the pancreatic juice.(ABSTRACT TRUNCATED AT 250 WORDS)
D Sautereau; M Chovet; J Chariot; A Tsocas; C Rozé
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pancreas     Volume:  4     ISSN:  0885-3177     ISO Abbreviation:  Pancreas     Publication Date:  1989  
Date Detail:
Created Date:  1989-09-07     Completed Date:  1989-09-07     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8608542     Medline TA:  Pancreas     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  210-8     Citation Subset:  IM    
INSERM U 239, Faculté de Médecine Xavier Bichat, Paris, France.
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MeSH Terms
Dinoprostone / pharmacology*
Dioxanes / pharmacology
Dose-Response Relationship, Drug
Injections, Intraventricular
Pancreas / drug effects
Pancreatic Juice / secretion*
Prazosin / pharmacology
Prostaglandins E, Synthetic / pharmacology*
Rats, Inbred Strains
Vagus Nerve / physiology
Yohimbine / pharmacology
Reg. No./Substance:
0/Dioxanes; 0/Prostaglandins E, Synthetic; 146-48-5/Yohimbine; 19216-56-9/Prazosin; 363-24-6/Dinoprostone; 73121-56-9/Enprostil; 79944-58-4/Idazoxan

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