Document Detail

Central and peripheral effects of the non-neural substances on respiration before and after vagotomy.
MedLine Citation:
PMID:  9352622     Owner:  NLM     Status:  MEDLINE    
The central effects of capsaicin, veratrine, histamine and bradykinin were studied by injecting them directly into the oerebrospinal fluid and their peripheral effects were examined by injecting into femoral vein. Our experiments were performed in Na-pentobarbital-anaesthetized dogs. Tidal volume (VT), respiratory frequency (f/min), systemic arterial pressure (BP) were recorded. A significant increase in f, and an initial apnea or hypoventilation followed by a significant increase in VT were observed with central and peripheral capsaicin. Vagotomy removed the peripheral VT response, but not the central one. While central capsaicin administration increased BP, peripheral administration decreased. After vagotomy, a significant increase was observed in BP for both administrations. Respiratory responses to central and peripheral administrations of veratrine were similar to those of capsaicin. Significant increases were observed in f and VT of the intact group in response to central and peripheral administration of histamine. Response to peripheral administration disappeared after vagotomy. While central and peripheral bradykinin increased VT significantly, there was no significant change in f. Vagotomy only removed the increase in VT in response to peripheral administration. In conclusion, respiratory responses to central administration of capsaicin and veratrine are due to direct effects of these substances on respiratory neurons. In peripheral administration, disappearance of the responses after vagotomy indicate that the responses are brought about by stimulation of the lung receptors.
G Sahin; T Oruç; G Simşek; I Güner
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Tohoku journal of experimental medicine     Volume:  182     ISSN:  0040-8727     ISO Abbreviation:  Tohoku J. Exp. Med.     Publication Date:  1997 Aug 
Date Detail:
Created Date:  1997-12-22     Completed Date:  1997-12-22     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0417355     Medline TA:  Tohoku J Exp Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  297-307     Citation Subset:  IM    
Physiology Department, Cerrahpaşa Faculty of Medicine, University of Istanbul, Turkey.
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MeSH Terms
Blood Pressure / drug effects
Bradykinin / pharmacology
Capsaicin / pharmacology
Central Nervous System / drug effects,  physiology*
Histamine / pharmacology
Nerve Fibers / drug effects
Peripheral Nervous System / drug effects,  physiology*
Pulmonary Stretch Receptors / drug effects
Respiratory Function Tests
Respiratory Mechanics / drug effects*
Veratridine / pharmacology
Reg. No./Substance:
404-86-4/Capsaicin; 51-45-6/Histamine; 58-82-2/Bradykinin; 71-62-5/Veratridine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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