Document Detail

Central osmotic regulation of sympathetic nerve activity.
MedLine Citation:
PMID:  12492778     Owner:  NLM     Status:  MEDLINE    
AIM: In this review, we will focus on the central neural mechanisms that couple osmotic perturbations to changes in sympathetic nerve discharge, and the possible impact these actions have in cardiovascular diseases such as arterial hypertension and congestive heart failure. RESULTS: Changes in extracellular fluid osmolality lead to specific regulatory responses in defence of body fluid and cardiovascular homeostasis. Systemic hyperosmolality is well known to stimulate thirst and the release of antidiuretic hormone. These responses are largely due to osmosensing neurones in the forebrain lamina terminalis and hypothalamus and are critical elements in a control system that operates to restore body fluid osmolality. An equally important, but less characterized, target of central osmoregulatory processes is the sympathetic nervous system. CONCLUSION: Understanding the neurobiology of sympathetic responses to changes in osmolality has important implications for body fluid and cardiovascular physiology. By stabilizing osmolality, vascular volume is preserved and thereby relatively normal levels of cardiac output and arterial pressure are maintained.
G M Toney; Q H Chen; M J Cato; S D Stocker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Acta physiologica Scandinavica     Volume:  177     ISSN:  0001-6772     ISO Abbreviation:  Acta Physiol. Scand.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-20     Completed Date:  2003-04-28     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0370362     Medline TA:  Acta Physiol Scand     Country:  England    
Other Details:
Languages:  eng     Pagination:  43-55     Citation Subset:  IM    
Department of Physiology: MC 7756, The University of Texas Health Science Center, San Antonio, TX 78229-3900, USA.
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MeSH Terms
Blood Pressure / physiology
Extracellular Space / physiology*
Heart Failure / physiopathology
Hypertension / physiopathology
Intracellular Fluid / physiology
Kidney / physiology
Osmolar Concentration
Prosencephalon / physiology
Sodium Chloride / metabolism
Sympathetic Nervous System / physiology*
Vasopressins / metabolism
Water-Electrolyte Balance / physiology
Grant Support
Reg. No./Substance:
11000-17-2/Vasopressins; 7647-14-5/Sodium Chloride

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